Faecalibacterium prausnitzii strain cncm 1-4573 for the treatment and prevention of gastrointestinal inflammation
A CNCMI-4573, Przewalski's stool technology, applied in the field of Faecalibacterium Przetii strains, can solve problems such as lack of proper treatment and inability to treat inflammatory diseases
Pending Publication Date: 2019-02-05
INST NAT DE RECH POUR LAGRICULTURE LALIMENTATION & LENVIRONNEMENT +2
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Problems solved by technology
Some of these inflammatory diseases remain untreatable or not properly treated
Method used
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[0066] The Faecalibacterium prausnitzii strain according to the present invention (deposited by CNCM under the deposit number CNCM I-4573) was tested for its ability to regulate the immune response in vitro and in vivo and to have a direct effect on enteritis, and compared it with Two other F. prausnitzii strains, A2-165 and CNCM I-4575, were compared.
[0067] In the in vitro experiments, two different cell models were used: HT-29 and PBMC.
[0068] For in vivo experiments, a murine colitis model was used.
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The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and / or prevention of an inflammatorygastrointestinal illness in an individual.
Description
technical field [0001] The present invention relates to a strain of Faecalibacterium prausnitzii for use in the treatment and prophylaxis of inflammatory gastrointestinal diseases (IBD), especially inflammatory bowel disease (IBD) in an individual. Background technique [0002] Inflammation is a natural biological process that forms a normal part of the response to disease or infection and helps protect the body from internal or external attacks. [0003] However, dysfunction of inflammatory mechanisms, especially persistent or overabundant inflammation, can cause painful diseases and endanger the lives of patients. These diseases include, for example, skin diseases, bowel diseases, neurological disorders, arthritis and autoimmune diseases. Some of these inflammatory diseases remain untreatable or without proper treatment. [0004] Therefore, research and finding new anti-inflammatory therapeutic strategies constitute a major topic of medical and biomedical research. [0...
Claims
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IPC IPC(8): A61K35/741C12R1/01A23L33/135A61P1/00A61P29/00
CPCA61K35/741A23L33/135A23V2200/32A23V2002/00A23V2200/3204A61P1/00C12R2001/01C12N1/205A61K35/74
Inventor 菲利普·朗格拉丽贝卡·马丁·罗西克路易斯·贝穆德兹·胡玛兰弗洛里安·谢安哈利·索科尔
Owner INST NAT DE RECH POUR LAGRICULTURE LALIMENTATION & LENVIRONNEMENT