Disodium sulfodehydroabietate (DSDA) and composition and application thereof

A technology of disodium abietic acid and dehydroabietic acid, which is applied in drug combination, digestive system, drug delivery, etc.
CN101590031AActive Publication Date: 2009-12-02ZHEJIANG ASEN PHARMA
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
ZHEJIANG ASEN PHARMA
Publication Date
2009-12-02

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Abstract

The invention discloses disodium sulfodehydroabietate (DSDA) and a composition, a preparation method and application thereof in medicaments for preventing hyperacid peptic ulcer and gastrointestinal inflammation. A patent application disclosed by CN00818150.0 is of the opinion that monosodium sulfodehydroabietate is superior to disodium salt, but does not further disclose test conditions and data conclusion; moreover, the pharmacological action and clinical application of the disodium salt deserve further research. The invention compares the in-vitro acid making effects of monosodium salt and the disodium salt, the dissolution of the monosodium salt and the disodium salt in artificial gastric juice and intestinal juice as well as the clinical efficacies in treating gastric ulcer, acute gastritis and acute attack of chronic gastritis. Results show that DSDA has the advantages that DSDA has stronger acid-making capability during treating the gastric ulcer, acute gastritis and acute attack of chronic gastritis and faster dissolution speed in stomach and intestine; and medicaments prepared from the DSDA have better curative effect and quick response.
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Description

technical field

[0001] The present invention relates to sulfonated dehydroabietic acid disodium, in particular to sulfonated dehydroabietic acid disodium, its composition, preparation method and its use in medicines for preventing and treating hyperacidity peptic ulcer and gastrointestinal inflammatory disease application. Background technique

[0002] The compound sulfonated dehydroabietic acid was reported as early as the 1930s as an intermediate for the preparation of pure dehydroabietic acid; its derivatives were reported in the 1970s as detergents, but as drugs, especially for gastric Drug research for the prevention or treatment of intestinal diseases is very rare.

[0003] Gastrointestinal diseases are one of the common and frequently-occurring diseases, among which ulcer disease is the most common, and the total incidence rate accounts for about 10-20% of the world's population. Gastrointestinal diseases include: peptic ulcer, gastritis, intestinal disease (here re...

Claims

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