Open surface graphitic materials for adsorption of cytokines from blood
A technology of cytokines and blood, applied in blood circulation treatment, blood filtration, suction equipment, etc., can solve problems such as elevated cytokine levels
Inactive Publication Date: 2019-02-05
DREXEL UNIV
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- Description
- Claims
- Application Information
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Problems solved by technology
Although produced by the body and perform cell signaling and communication functions under physiological conditions, the rapid increase in cytokine levels under pathological conditions - a condition also known as "cytokine storm" - has disastrous effects
Method used
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Embodiment approach
[0074] The following list of embodiments is intended to supplement rather than replace or supersede the preceding description.
Embodiment approach 1
[0075] Embodiment 1. A method of removing protein from blood or a blood product, the method comprising contacting the blood or blood product with a carbon form having slit-shaped mesopores and macropores, the pore sizes being selected to match The proteins are comparable in size. In certain instances of this embodiment, said contacting results in removal of at least 80% of said protein from said blood or blood product in less than 120 minutes. In other cases, the contacting is accomplished at or near ambient temperature (eg, 10 to 35° C.), although higher or lower temperatures can also be used.
Embodiment approach 2
[0076] Embodiment 2. The method of embodiment 1, wherein the carbon form comprises thermally expanded graphite (TEG). Various aspects of the TEG are described elsewhere herein.
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Abstract
The present disclosure is directed to methods of removing proteins, including cytokines, from blood and blood products, the methods comprising contacting the blood or blood product with a form of carbon having high graphitic contents and slit-shaped mesopores and macropores, the pore size dimensions chosen to be comparable to the size of the proteins, wherein the contacting results in the removalof high levels of the protein from the blood or blood product in minutes or hours.
Description
[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 341,661, filed May 26, 2016, and U.S. Provisional Patent Application No. 62 / 353,078, filed June 22, 2016. Both applications mentioned above are hereby incorporated by reference in their entirety. [0003] government rights [0004] This invention was made with Government support under Contract #1518999 awarded by the National Science Foundation. The US Government has certain rights in this invention. technical field [0005] The present disclosure relates to purification of blood and blood products by removal of cytokines from blood and blood products. Background technique [0006] High levels of pro-inflammatory cytokines are associated with high lethality in serious conditions such as sepsis and Ebola virus disease. Although produced by the body and perform cell signaling and communication functions under physiological conditions, the ...
Claims
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IPC IPC(8): A61M1/34A61M1/36A61M37/00B01J20/32B01J20/30B01J20/26
CPCA61M1/3679A61M1/3486B01J20/20B01J20/28083B01J20/28085B01J20/205A61M2202/0445A61M2202/07B01J20/321
Inventor 尤里·戈高齐斯瓦迪姆·莫恰林尼古拉斯·佩斯卡托雷
Owner DREXEL UNIV