Compound puffer liver oil composition as well as preparation method and application thereof

A composition, technology of puffer fish, applied in the field of traditional Chinese medicine, can solve problems such as lack of theoretical basis, failure to meet food hygiene standards, and inability to be used in food or medicine, etc., to achieve amplified curative effect, significant therapeutic effect, inhibition of dependence and tolerance sexual effect

Inactive Publication Date: 2019-02-15
泰州市康特生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] 2. Part of the research on tetrodotoxin in the prior art has entered into a misunderstanding
[0013] 3. The existing technology mistakenly believes that the active ingredient of puffer fish liver oil is a trace amount of tetrodotoxin
[0014] Fourth, the prior art has no clear description of the anti-cancer mechanism of puffer fish liver oil
(Liu Changqing et al. "Experimental Research on the Anti-tumor and Anti-metastasis Effects of Detoxified Puffer Fish Liver Oil". Chinese Journal of Integrated Traditional Chinese and Western Medicine. 1995, Volume 15, No. 9) These discussions have certain practical significance for the application of puffer fish liver oil, but the real application of puffer fish liver oil The application of liver oil as an anticancer drug still lacks more sufficient theoretical basis
[0015] Five, the prior art only sees that the plant essential oil composition is used for the treatment of soft tissue cancer
[0016] 6. In the prior art, there is no report on the joint application of puffer fish liver oil and various vegetable oils
[0017] Seven, the prior art fails to carry out deep processing suitable for food or medicine to puffer fish liver oil
In the existing literature and patents, there is no statement that sodium hydroxide or other alkalis are used to saponify crude puffer fish liver oil. This unsaponified puffer fish liver oil cannot achieve detoxification, deacidification, deodorization, degumming, Requirements for decolorization and deodorization, does not meet food hygiene standards, and cannot be used for food or medicine

Method used

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  • Compound puffer liver oil composition as well as preparation method and application thereof
  • Compound puffer liver oil composition as well as preparation method and application thereof
  • Compound puffer liver oil composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1. the preparation of refining puffer fish liver oil

[0073] ①Take 20kg of cleaned puffer fish liver (or the leftover liver residue after extracting tetrodotoxin), heat it in a water bath at a constant temperature of 98°C, and keep it warm for 15 hours. Take the clear oil from the upper layer to obtain 10 kg of crude puffer fish liver oil, and set it aside.

[0074] ② Prepare an aqueous sodium hydroxide solution with a concentration of 30% w / v, take 3000ml, add it to the above 10kg crude puffer fish liver oil, control the temperature at 60-80°C, stir for 25 minutes, keep the temperature constant, let it settle naturally, and take the supernatant for later use.

[0075] ③Use a centrifuge to separate the chaotic oil feet, remove the saponified matter, leave the clear oil and combine it with the supernatant, and set aside.

[0076] ④Prepare 10kg of 8% w / v saline solution, control the temperature at 60-80°C, dissolve the above-mentioned puffer fish liver oil cle...

Embodiment 2

[0078] Example 2. The preparation of the compound fugu liver oil composition for the treatment of cancer

[0079] ①Take 8kg of refined puffer fish liver oil, add 1kg of magnolia seed pressed oil, stir evenly, and set aside.

[0080] ②Take 100g each of scallion oil, citrus oil, turmeric oil, zedoary oil, ginger oil, bay leaf oil, garlic oil, mugwort leaf oil, vitex oil, and perilla leaf oil, totaling 1000g (volatile oil), mix with the above ①, and stir Evenly, 10 kg of puffer fish liver oil and vegetable oil composition were obtained. (Vegetable oil is selected from Jiangxi Hengcheng Natural Perfume Oil Co., Ltd.)

[0081] ③ 10kg of the above composition is made into 20,000 soft capsules, the net weight of the composition in each capsule is 0.5g, and the content of each volatile oil is 1%, 10% in total, the content of pressed oil of Tiannv magnolia seed is 10%, and the content of refined puffer fish liver oil 80%.

[0082] ④The tentative name of this combined preparation: "P...

Embodiment 3

[0083] Example 3. Preparation of Compound Fugu Liver Oil Composition for Treatment of Advanced Cancer and Cancer Pain

[0084] ① Take 7kg of refined puffer fish liver oil, add 0.9kg of pressed oil of Brucea javanica, stir well, and set aside.

[0085] ② Take scallion oil, citrus oil, Atractylodes atractylodes oil, geranium oil, turmeric oil, asarum oil, zedoary oil, angelica oil, ferulic oil, trigonum oil, perilla leaf oil, comfrey oil, perilla leaf oil, Each 150g of vitex leaf oil adds up to 2100g (volatile oil), mixes with above-mentioned ①, stirs evenly, obtains fugu liver oil and vegetable oil composition 10kg. (Vegetable oil is selected from Jiangxi Hengcheng Natural Perfume Oil Co., Ltd.)

[0086] 3. above-mentioned composition 10kg is made into 20,000 soft capsules, the composition net weight of every capsule is 0.5g, wherein each volatile oil content is 1.5%, totally 21%, javanica javanica oil content 9%, refined puffer fish liver oil content 70%.

[0087] ④The tenta...

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Abstract

The invention provides a compound puffer liver oil composition as well as a preparation method and application thereof. The compound puffer liver oil composition comprises an active ingredient and / ora pharmaceutically acceptable carrier, wherein the active ingredient consists of puffer liver oil and vegetable oil; the puffer liver oil is puffer liver oil extracted from liver of a puffer containing tetrodotoxin in vivo; and the vegetable oil is volatile oil and / or pressed oil extracted from natural plants. The composition provided by the invention is used for treating various cancers or leukemia, can be used for skilling and wounding cancer cells or enabling the cancer cells to be reversed and can be used for inhibiting the growth or spread of the cancer cells and relieving or eliminatingterminal cancer pain. Meanwhile, the curative effects of analgesics, chemotherapeutic drugs and targeted drugs can also be improved, and the dependence, tolerance and side effects of the analgesics, the chemotherapeutic drugs and the targeted drugs can be relieved or eliminated. The compound puffer liver oil composition belongs to a broad spectrum anti-cancer drug which is safe and efficient, takes effect quickly, is low in price and has no side effect. The compound puffer liver oil composition can also be used for non-cancer analgesia and drug de-addiction.

Description

technical field [0001] The invention relates to a compound puffer fish liver oil composition, which is a compound Chinese patent medicine prepared from puffer fish liver oil and vegetable oil on the basis of traditional Chinese medicine and folk prescriptions, and belongs to the field of traditional Chinese medicine. Background technique [0002] Chinese medicine is the world's largest medical treasure house. The inventor has long been engaged in the research of tetrodotoxin and its esterified product, and found that the tetrodotoxin lipid product has no toxicity, not only has anti-cancer, analgesic and withdrawal effects, but also can amplify the curative effect of shared drugs, and inhibit the dependence and tolerance of shared drugs. acceptability and side effects. The application of the present invention shows that the Chinese patent medicine developed by using the tetrodotoxin lipid as the basic raw material can realize the treatment of both the symptoms and root cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/60A61K45/06A61K36/9068A61K36/9066A61K36/902A61P35/00A61P35/02A61P35/04A61P29/00A61P25/30A61P25/36A61P19/02
CPCA61K36/8962A61K36/902A61K36/9066A61P29/00A61P35/00A61K35/60A61K36/185A61K36/23A61K36/232A61K36/268A61K36/284A61K36/30A61K36/535A61K36/752A61K36/85A61K9/48A61P35/04A61P35/02A61K2300/00
Inventor 赵继红赵琦赵越洋汤波澜
Owner 泰州市康特生物工程有限公司
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