Anti-adhesion rinse solution for surgery

A surgical operation and anti-adhesion technology, which is applied in the medical field, can solve problems such as unsatisfactory product effects, and achieve the effects of excellent biological barrier performance, increased mobility, and excellent tissue compatibility

Inactive Publication Date: 2019-02-26
于晓彤
View PDF13 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in addition to the barrier film of medical devices, the most commonly used method to prevent postoperative tissue adhesion is to reduce inflammation and dissolve fibrin through drugs. In recent years, a variety of anti-adhesion materials have been developed, but for anti-adhesion materials Said that on the basis of anti-adhesion, it should be able to quickly degrade and minimize residues in the body, but the current product effect is not ideal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-adhesion rinse solution for surgery
  • Anti-adhesion rinse solution for surgery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method for anti-adhesion flushing fluid for surgery, comprising the following steps:

[0029] (1) Add carboxymethylcellulose sodium into water for injection, stir until dissolved, then add γ-polyglutamic acid and L-threonine, stir for 5 hours to obtain a mixed solution, and set aside;

[0030] (2) Adding polylactic acid-glycolic acid copolymer to the oleic acid heterogeneous liposomes, ultrasonic emulsification treatment to obtain the multiphase liposomes, and then adding it to the mixed solution obtained in step (1);

[0031] (3) Add carboxymethyl chitosan, ultrasonically oscillate for 12 hours, and sterilize with damp heat at 121°C to obtain the product;

[0032] Among them, the mass volume of sodium carboxymethylcellulose, γ-polyglutamic acid, L-threonine, polylactic acid-glycolic acid copolymer, oleic acid multiphase liposome, carboxymethyl chitosan and water for injection The ratio is 0.01g:0.06g:0.03g:0.02g:2g:0.08g:100mL.

[0033] Wherein, in step...

Embodiment 2

[0036] A preparation method for anti-adhesion flushing fluid for surgery, comprising the following steps:

[0037] (1) Add carboxymethylcellulose sodium into water for injection, stir until dissolved, then add gamma-polyglutamic acid and L-threonine, stir for 8 hours to obtain a mixed solution, set aside;

[0038] (2) Adding polylactic acid-glycolic acid copolymer to the oleic acid heterogeneous liposomes, ultrasonic emulsification treatment to obtain the multiphase liposomes, and then adding it to the mixed solution obtained in step (1);

[0039] (3) Add carboxymethyl chitosan, ultrasonically oscillate for 24 hours, and sterilize with damp heat at 121°C to obtain the product;

[0040] Among them, the mass volume of sodium carboxymethylcellulose, γ-polyglutamic acid, L-threonine, polylactic acid-glycolic acid copolymer, oleic acid multiphase liposome, carboxymethyl chitosan and water for injection The ratio is 0.02g:0.08g:0.05g:0.03g:3g:0.1g:100mL.

[0041] Wherein, in step ...

Embodiment 3

[0044] A preparation method for anti-adhesion flushing fluid for surgery, comprising the following steps:

[0045] (1) Add carboxymethylcellulose sodium into water for injection, stir until dissolved, then add γ-polyglutamic acid and L-threonine, stir for 5 hours to obtain a mixed solution, and set aside;

[0046] (2) Adding polylactic acid-glycolic acid copolymer to the oleic acid heterogeneous liposomes, ultrasonic emulsification treatment to obtain the multiphase liposomes, and then adding it to the mixed solution obtained in step (1);

[0047] (3) Add carboxymethyl chitosan, ultrasonically oscillate for 24 hours, and sterilize with damp heat at 121°C to obtain the product;

[0048] Among them, the mass volume of sodium carboxymethylcellulose, γ-polyglutamic acid, L-threonine, polylactic acid-glycolic acid copolymer, oleic acid multiphase liposome, carboxymethyl chitosan and water for injection The ratio is 0.01g:0.08g:0.03g:0.03g:2g:0.1g:100mL.

[0049] Wherein, in step ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention provides an anti-adhesion rinse solution for surgery. A preparation method for the anti-adhesion rinse solution comprises the following steps: (1) adding sodium carboxymethyl cellulose into water for injection, carrying out stirring until the sodium carboxymethyl cellulose is dissolved, then adding gamma-polyglutamic acid and L-threonine, performing stirring to obtain a mixed solution, and putting the mixed solution aside for subsequent usage; (2) adding a polylactic acid-glycolic acid copolymer into an oleic acid polyphase liposome, carrying out ultrasonic emulsification to obtain a polyphase liposome, and then adding the polyphase liposome into the mixed solution obtained in the step (1); and (3) adding carboxymethyl chitosan, and successively performing ultrasonic oscillation and sterilization so as to obtain the anti-adhesion rinse solution. The anti-adhesion rinse solution of the invention has good anti-adhesion effect, is easy to degrade, and has good bactericidal performance.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an anti-adhesion flushing solution for surgery. Background technique [0002] Tissue adhesions are very prone to occur after surgery. The so-called adhesion refers to the abnormal structure formed by the fibrous band of connective tissue and the adjacent tissue or organ. This is the process that patients must go through during the postoperative healing process. If adhesions occur during abdominal or pelvic bone surgery, it will cause serious complications, such as: abdominal, pelvic, etc. can cause adhesive intestinal obstruction, recurrent laryngeal nerve injury after thyroid surgery, and pelvic tissue adhesions. infertility etc. [0003] Tissue adhesions can be caused by many reasons, such as: trauma during surgery, inflammation caused by ischemia, presence of foreign bodies in the body, bacterial infection at bleeding sites or exposed wounds. [0004] At present, in additio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K31/785A61K9/08A61K47/38A61P41/00A61P31/02A61P17/02A61K31/198A61K31/717A61K31/722
CPCA61K9/0014A61K9/08A61K31/198A61K31/717A61K31/722A61K31/785A61K47/34A61K47/38A61K2300/00
Inventor于晓彤
Owner于晓彤