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as 4 the s 4 The use of joint application with jq1 in pharmacy

A kind of as4s4, 1.as4s4 technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, anti-tumor drugs, etc., can solve the problems of limited effect of BET inhibitors and failure of tumor-bearing mice to achieve ideal cancer remission

Active Publication Date: 2020-12-15
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in advanced solid tumors, BET inhibitors often have limited efficacy and do not achieve optimal cancer remission in tumor-bearing mice in most preclinical tumor models
These findings demonstrate that solid cancers may be inherently resistant to BET inhibitor monotherapy, posing serious challenges to the potential clinical application of this new class of drugs

Method used

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  • as <sub>4</sub> the s <sub>4</sub> The use of joint application with jq1 in pharmacy
  • as <sub>4</sub> the s <sub>4</sub> The use of joint application with jq1 in pharmacy
  • as <sub>4</sub> the s <sub>4</sub> The use of joint application with jq1 in pharmacy

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Experimental program
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Embodiment Construction

[0024] The specific implementation manners of the present invention will be described below in conjunction with the accompanying drawings.

[0025] In this embodiment, an As 4 S 4 and the use of JQ1 in the preparation of drugs that induce the release of cytochrome c from mitochondria into cytoplasm. As 4 S 4 The dosage of JQ1 is 1 to 5 μM, and the dosage of JQ1 is 1 to 10 μM.

[0026] In this embodiment, an As 4 S 4 and the application of JQ1 in the preparation of drugs for inhibiting the migration of gastric cancer cells.

[0027] As 4 S 4 The dosage of JQ1 is 1 μM, and the dosage of JQ1 is 1 to 10 μM.

[0028] The following is a concrete experiment to illustrate As 4 S 4 The effect of combined application with JQ1.

[0029] Cell Culture and Reagents

[0030] AGS, MGC803, HCT116 and SW480 cells were obtained from the Chinese Academy of Sciences Committee Type Culture Cell Bank (China). AGS cells were grown in DMEM / F12 medium (Hyclone, USA) containing 10% FBS; MG...

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Abstract

The invention provides combined application of As4S4 and JQ1 to preparation of medicines, particularly provides application of As4S4 and JQ1 to preparation of medicines for inducing cytochrome C to bereleased from mitochondria to cytoplasm and relates to application of As4S4 and JQ1 to preparation of medicines for inhibiting migration of gastric cancer cells. Through the combined application of As4S4 and JQ1 to preparation of the medicines, the inhibition effect on tumor cells can be better achieved.

Description

technical field [0001] The present invention relates to an As 4 S 4 The application in combination with JQ1 in pharmacy belongs to the field of medicine. Background technique [0002] Stomach and colon cancers remain the leading causes of cancer death in the United States. Gastric cancer (GC) is a malignant tumor derived from gastric epithelial cells with a poor prognosis. Gastric cancer is also the third leading cause of cancer death worldwide. The prognosis of patients with advanced colorectal cancer (CRC) remains unsatisfactory due to metastatic propensity and chemotherapy resistance. Despite recent advances in cancer treatment methods, including surgical approaches, radiotherapy, chemotherapy, and novel molecularly targeted therapies for gastric and colon cancers, the prognosis remains unsatisfactory. Therefore, there is still a need to continue to investigate new treatments and strategies to improve the prognosis of gastric and colon cancer patients. [0003] A cl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/36A61P35/00A61K31/551
CPCA61K31/551A61K33/36A61P35/00A61K2300/00
Inventor 陈思宇谭圳张秀丽康婷仝营营张莲丁文评
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE