Application of plasma exosome miR-455-3p as early liver cancer diagnostic marker

A technology for early-stage liver cancer and exosomes, which is applied in the fields of biotechnology and medicine to achieve the effects of accurate quantification, broad market application prospects, and easy clinical development.

Pending Publication Date: 2019-03-08
BEIJING YOUAN HOSPITAL CAPITAL MEDICAL UNIV +1
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its relationship with li...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of plasma exosome miR-455-3p as early liver cancer diagnostic marker
  • Application of plasma exosome miR-455-3p as early liver cancer diagnostic marker
  • Application of plasma exosome miR-455-3p as early liver cancer diagnostic marker

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1. Research objects: 22 patients with early liver cancer from Beijing You'an Hospital Affiliated to Capital Medical University from July 2016 to December 2017 were selected as the research group. Among them, there were 10 males and 12 females. Aged 41 to 76 years old, with an average of (60.1±10.6) years old. The diagnostic criteria for early liver cancer are based on the "Primary Liver Cancer Diagnosis and Treatment Standards (2017 Edition)" issued by the National Health and Family Planning Commission. All liver cancer patients whose plasma is collected have a tumor volume of ≤5 cm and are single tumors. Chronic HBV infection group included 25 patients, including 13 males and 12 females, aged 40 to 65 years, with an average of (52.2±9.7) years old. The diagnostic criteria for chronic hepatitis B are based on the "Diagnostic Criteria for Chronic Hepatitis B (2015 Edition)" issued by the Infectious Diseases Branch of the Chinese Medical Association's Hepatology Branch. ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the fields of biotechnology and medicine, and particularly relates to application of plasma exosome miR-455-3p as an early liver cancer diagnostic marker.

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and in particular relates to the application of plasma exosome miR-455-3p as a diagnostic marker for liver cancer (early stage). Background technique [0002] Primary liver cancer is one of the most common malignant tumors in my country, its incidence rate ranks fourth among all malignant tumors, and its case fatality rate ranks third, among which hepatocellular carcinoma (HCC) accounts for all primary liver cancers. 85% to 90% of malignant liver cancer. The poor prognosis of HCC is mainly attributed to its hidden pathogenic process, so many patients are in the middle and advanced stages when they are first diagnosed, and they lose the opportunity for radical treatment. As the main serological marker, AFP has a sensitivity of 40-65% and a specificity of 76-90%. Nearly 1 / 3 of liver cancer patients are negative for AFP. Therefore, AFP is not ideal as an early diagnosis indicator. Theref...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C12Q1/6886C12Q1/686C12N15/113
CPCC12Q1/686C12Q1/6886C12Q2600/158C12Q2600/178C12Q2561/113C12Q2563/107C12Q2545/114
Inventor 李伟华李传云陈德喜金荣华李秀惠侯慧兰
Owner BEIJING YOUAN HOSPITAL CAPITAL MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap