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Application of plasma exosome miR-455-3p as early liver cancer diagnostic marker

A technology for early-stage liver cancer and exosomes, which is applied in the fields of biotechnology and medicine to achieve the effects of accurate quantification, broad market application prospects, and easy clinical development.

Pending Publication Date: 2019-03-08
BEIJING YOUAN HOSPITAL CAPITAL MEDICAL UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its relationship with liver cancer has not been reported before

Method used

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  • Application of plasma exosome miR-455-3p as early liver cancer diagnostic marker
  • Application of plasma exosome miR-455-3p as early liver cancer diagnostic marker
  • Application of plasma exosome miR-455-3p as early liver cancer diagnostic marker

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Embodiment 1

[0046] 1. Research objects: 22 patients with early liver cancer from Beijing You'an Hospital Affiliated to Capital Medical University from July 2016 to December 2017 were selected as the research group. Among them, there were 10 males and 12 females. Aged 41 to 76 years old, with an average of (60.1±10.6) years old. The diagnostic criteria for early liver cancer are based on the "Primary Liver Cancer Diagnosis and Treatment Standards (2017 Edition)" issued by the National Health and Family Planning Commission. All liver cancer patients whose plasma is collected have a tumor volume of ≤5 cm and are single tumors. Chronic HBV infection group included 25 patients, including 13 males and 12 females, aged 40 to 65 years, with an average of (52.2±9.7) years old. The diagnostic criteria for chronic hepatitis B are based on the "Diagnostic Criteria for Chronic Hepatitis B (2015 Edition)" issued by the Infectious Diseases Branch of the Chinese Medical Association's Hepatology Branch. ...

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Abstract

The invention belongs to the fields of biotechnology and medicine, and particularly relates to application of plasma exosome miR-455-3p as an early liver cancer diagnostic marker.

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and in particular relates to the application of plasma exosome miR-455-3p as a diagnostic marker for liver cancer (early stage). Background technique [0002] Primary liver cancer is one of the most common malignant tumors in my country, its incidence rate ranks fourth among all malignant tumors, and its case fatality rate ranks third, among which hepatocellular carcinoma (HCC) accounts for all primary liver cancers. 85% to 90% of malignant liver cancer. The poor prognosis of HCC is mainly attributed to its hidden pathogenic process, so many patients are in the middle and advanced stages when they are first diagnosed, and they lose the opportunity for radical treatment. As the main serological marker, AFP has a sensitivity of 40-65% and a specificity of 76-90%. Nearly 1 / 3 of liver cancer patients are negative for AFP. Therefore, AFP is not ideal as an early diagnosis indicator. Theref...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12Q1/686C12N15/113
CPCC12Q1/686C12Q1/6886C12Q2600/158C12Q2600/178C12Q2561/113C12Q2563/107C12Q2545/114
Inventor 李伟华李传云陈德喜金荣华李秀惠侯慧兰
Owner BEIJING YOUAN HOSPITAL CAPITAL MEDICAL UNIV
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