Selenium sodium alginate and selenium chitosan coated probiotic double-layer microcapsule as well as preparation method and application thereof

A technology for selenizing chitosan and sodium alginate, which is applied in the field of medicine and biology, and achieves the effects of good biosafety and biocompatibility, large embedding capacity, and improved survival rate.
CN109453207AActive Publication Date: 2019-03-12广东南芯医疗科技有限公司

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
广东南芯医疗科技有限公司
Publication Date
2019-03-12

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Abstract

The invention discloses a selenium sodium alginate and selenium chitosan coated probiotic double-layer microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps of treating sodium alginate and chitosan with sodium selenite to prepare selenium sodium alginate and selenium chitosan; embedding probiotics with the selenium sodium alginate and the selenium chitosan; and using Ca<2+> crosslinking to acquire the probiotic double-layer microcapsule. The selenium sodium alginate and selenium chitosan coated probiotic double-layer microcapsule provided by the invention can exert the effect of probiotic colonization to improve intestinal microecology and can further replenish selenium elements essential for a human body to enhance the immunity of an organism and further strengthen the gain effect of the probiotics to the human body.
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Description

technical field

[0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a probiotic bilayer microcapsule coated with selenized sodium alginate and selenized chitosan, a preparation method and an application thereof. Background technique

[0002] Probiotics change the composition of the flora in a certain part of the host through colonization, thereby producing a single or a mixture of microorganisms with a clear composition that is beneficial to the health of the host. As the organ with the highest abundance of microbial flora in the human body, proper supplementation of probiotics can improve intestinal function and have positive significance for maintaining human health. However, there are digestive juices such as gastric acid and bile salts in the human digestive tract, which have a strong antibacterial and bactericidal effect, which poses a huge obstacle to the colonization of oral probiotics.

[0003] Sodium alginate is...

Claims

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