A radioactive iodine-labeled gold nanomaterial and its preparation method and application

A radioactive iodine and gold nanotechnology, applied in the fields of nanomedicine and molecular imaging, can solve the problems of easy deiodination and poor stability, and achieve the effects of short time, simple operation and improved therapeutic effect.

Active Publication Date: 2021-07-13
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Solved technical problems: for the current 131 I labeling has disadvantages such as poor stability and easy deiodination. The invention provides a radioactive iodine-labeled gold nanomaterial and its preparation method and application. The present invention utilizes chloramine T or lodogen to pretreat Na 131 I and label Au NRs, the labeled by this method 131 I has higher radiochemical stability, is not easy to deiodine, and has better biological safety

Method used

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  • A radioactive iodine-labeled gold nanomaterial and its preparation method and application
  • A radioactive iodine-labeled gold nanomaterial and its preparation method and application
  • A radioactive iodine-labeled gold nanomaterial and its preparation method and application

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Embodiment 1

[0026] To 0.1 mL chloramine T aqueous solution (concentration is 0.3 mg·mL -1 ) was added 5 μL Na 131 I (radioactive dose is 0.05 mCi), vortex to mix the reaction for 30 seconds, add 1 mL of 1 mg∙mL -1 Au NRs were shaken for 1 hour at room temperature. Centrifuge at 10,000 rpm for 10 minutes and wash with deionized water three times. will react to get 131 I-Au NPs were dispersed in 5 mL deionized water, HS-PEG (molecular weight 5 kDa) was added, and 131 The molar ratio of I-Au NPs was 2:1, and the shaking reaction was continued for 5 hours, centrifuged at 10,000 rpm for 10 minutes, and washed three times with deionized water to obtain 131 I-Au NPs-PEG.

Embodiment 2

[0028] To 0.1 mL chloramine T aqueous solution (concentration is 0.3 mg·mL -1 ) was added 5 μL Na 131 I (radioactive dose is 0.5 mCi), vortex to mix the reaction for 30 seconds, add 1 mL of 1 mg∙mL -1 Au NRs were shaken for 1 hour at room temperature. Centrifuge at 10,000 rpm for 10 minutes and wash with deionized water three times. will react to get 131 I-Au NPs were dispersed in 5 mL deionized water, HS-PEG (3 kDa molecular weight) was added, and 131 The molar ratio of I-Au NPs was 1:1, and the shaking reaction was continued for 5 hours, centrifuged at 10000 rpm for 10 minutes, and washed three times with deionized water to obtain 131 I-Au NPs-PEG.

Embodiment 3

[0030]Dissolve 20 μg of chloroglycollil (Iodogen) in chloroform solution, then transfer the chloroglycollin chloroform solution into a glass tube and blow dry to remove the chloroform solution, then add 5 μL Na 131 I (radioactive dose of 0.5 mCi), vortex to mix the reaction for 30 seconds, add 1 mL of 2 mg∙mL -1 Au NRs were shaken for 1 hour at room temperature. Centrifuge at 10,000 rpm for 10 minutes and wash with deionized water three times. will react to get 131 I-Au NPs were dispersed in 5 mL deionized water, HS-PEG (molecular weight 5 kDa) was added, and 131 The molar ratio of I-Au NPs was 1:1, and the shaking reaction was continued for 5 hours, centrifuged at 10000 rpm for 10 minutes, and washed three times with deionized water to obtain 131 I-Au NPs-PEG.

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Abstract

The invention discloses a radioactive iodine-labeled gold nanometer material, a preparation method and an application thereof. The method specifically involves pretreatment of Na by chloramine T or lodogen oxidation 131 I, then mixed with Au NRs. At 100 μCi/1 mg‑20 mCi/1 mg 131 Under the dosage of I/Au NRs, this labeling method has no obvious effect on the morphology of Au NRs. However, compared with traditional labeling methods, this method obtains 131 I-labeled Au NRs have better radiochemical stability in vivo, which is beneficial for in vivo applications. In addition, this method obtains 131 I-labeled Au NRs can effectively enhance the delivery of radioactive substances to tumor cells and achieve long-term retention in tumor tissues, and can be used simultaneously for single-photon emission computed tomography (SPECT) imaging, radiotherapy and photothermal therapy.

Description

technical field [0001] The invention belongs to the fields of molecular imaging and nanomedicine, and relates to a radioactive iodine-labeled gold nanomaterial and its preparation method and application. Background technique [0002] Cancer is one of the major diseases that threaten human health and life, and its incidence is increasing day by day. At present, tumor treatment methods mainly include: surgery, radiation therapy, chemotherapy, magnetothermal therapy, photothermal therapy, photodynamic therapy, and immunotherapy. In vivo imaging technology provides important information for the progress of tumor treatment process. At present, the more commonly used tumor diagnostic imaging methods mainly include: X-ray computed tomography, ultrasound imaging, nuclear magnetic resonance imaging, nuclear medicine imaging technology (single photon emission computed tomography SPECT or positron emission computed tomography PET) and some optical Imaging techniques (such as fluoresc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/02A61K51/06A61K41/00A61P35/00A61K101/02
CPCA61K41/0052A61K51/02A61K51/065A61P35/00A61K2300/00
Inventor 孙晓莲王鹏马静文
Owner CHINA PHARM UNIV
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