Application of streptococcus pneumoniae protein to resisting infection of S. pneumoniae

A Streptococcus pneumoniae, protein technology, applied in the direction of immunoglobulin, antibacterial immunoglobulin, application, etc., can solve the problems of insufficient immunogenicity, adverse reactions, etc., to enhance resistance to Streptococcus pneumoniae infection, improve the body's IgG Effect of Antibody Response
CN109456393AActive Publication Date: 2019-03-12CHONGQING MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING MEDICAL UNIVERSITY
Publication Date
2019-03-12

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Abstract

The invention provides application of S. pneumoniae protein to resisting infection of S. pneumoniae. The endopeptidase O (PepO) of S. pneumoniae is a subcutaneous immunologic adjuvant, and the prepared S. pneumoniae protein vaccines have the good protection effects on resisting infection of S. pneumoniae through mixing and fusing expression of the subcutaneous immunologic adjuvant and 673rd to 863rd amino acid peptide fragment of zinc metal protease B (ZmpB).
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Description

technical field

[0001] The invention relates to the field of medical biotechnology, in particular to Streptococcus pneumoniae PepO, ZmpB 673-863 Use in the fight against Streptococcus pneumoniae infection, especially related to the use of Streptococcus pneumoniae endopeptidase O as an adjuvant for subcutaneous immunization, ZmpB 673-863 Use as a vaccine alone in combination with other adjuvants and PepO and ZmpB 673-863 Application of mixed or fusion expression in anti-streptococcus pneumoniae infection. Background technique

[0002] Streptococcus pneumoniae can cause pneumonia, meningitis and sepsis, and nearly 400,000 children under the age of 5 die every year worldwide due to Streptococcus pneumoniae infection. Pneumococcal sepsis is the leading cause of infant mortality in developing countries, where approximately 25% of deaths of children under 5 years of age and more than 1.2 million infant deaths are preventable each year. The current conjugate vaccine formulations...

Claims

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