Composition for treating liver cancer with fibrosis
A composition and fibrosis technology, applied in the directions of active ingredients of heterocyclic compounds, drug combinations, medical preparations containing active ingredients, etc., can solve the problem of limited effect of prolonging the survival period of patients with liver cancer, poor therapeutic effect of liver cancer, etc. problems, to achieve good therapeutic effect and prolong survival effect
Active Publication Date: 2020-09-11
TCM INTEGRATED HOSPITAL OF SOUTHERN MEDICAL UNIV
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Problems solved by technology
Among them, Sorafenib and Regorafenib, currently the only liver cancer targeted drugs, are approved for the treatment of inoperable or distantly metastatic hepatocellular carcinoma, but their effect on prolonging the survival of patients with liver cancer is very limited
And it does not have a good therapeutic effect on liver cancer with fibrosis
Method used
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[0033] A composition for treating liver cancer with fibrosis, the active ingredients of which include at least one SYK inhibitor and at least one multi-target kinase inhibitor against liver cancer.
[0034] As a further improvement of the above composition, the multi-target kinase inhibitors for liver cancer are Sorafenib and Reforafenib.
[0035] As a further improvement of the above composition, the SYK inhibitor is selected from GS-9973, R788, R406, and PRT062607.
[0036] The composition is used in the preparation of drugs for treating liver cancer accompanied by fibrosis, wherein the active ingredients of the composition include at least one SYK inhibitor and at least one multi-target kinase inhibitor against liver cancer.
[0037] As a further improvement of the above application, the multi-targeted kinase inhibitors for liver cancer are Sorafenib and Reforafenib.
[0038] As a further improvement of the above application, the SYK inhibitor is selected from GS-9973, R78...
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Disclosed is a composition for treating liver cancer accompanied by fibrosis, the active ingredients thereof comprising at least one SYK inhibitor and at least one multi-target kinase inhibitor against liver cancer. The inventor discovered, by means of experimentation, that by combined application of an SYK inhibitor targeting the liver micro-environment and the multi-target kinase inhibitor Sorafenib or Reforafenib against liver cancer, the SYK inhibitor enhances the cancer-inhibiting effect of Sorafenib or Reforafenib, and further extends the survival period of model mice, thus demonstrating that the combined application of SYK inhibitors and multi-target kinase inhibitors against liver cancer has a good therapeutic effect on liver cancer accompanied by fibrosis.
Description
technical field [0001] The invention relates to a composition for treating liver cancer with fibrosis. Background technique [0002] Hepatic fibrosis caused by various reasons is closely related to the occurrence of liver cancer. Most patients with liver cancer are accompanied by varying degrees of liver fibrosis. Moreover, current studies have found that the liver microenvironment in the context of fibrosis promotes the proliferation and invasion of liver cancer. In addition, liver fibrosis also reduces the choice of liver cancer treatment methods and reduces the therapeutic effect. However, there are currently no therapeutic strategies targeting HCC in the context of liver fibrosis. [0003] At present, surgery and interventional therapy are the main treatment methods for liver cancer, but a considerable number of liver cancer patients have entered the advanced stage of tumors when they are diagnosed, and have lost the opportunity for treatment. In addition, due to the ...
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IPC IPC(8): A61K45/06A61K31/44A61P35/00
CPCA61K31/44A61K45/06A61P35/00A61K2300/00
Inventor 洪健蒋煜川陈鹏戴冠齐
Owner TCM INTEGRATED HOSPITAL OF SOUTHERN MEDICAL UNIV