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Application of Qing dynasty palace longevity peach pill in preparation of drugs for treating and alleviating memory loss, amnesia and cognitive disorder

A technology for cognitive impairment and memory, which is applied in drug combination, pill delivery, and pharmaceutical formula, can solve problems such as unsatisfactory effects, large side effects, and mutual influence, so as to improve the ability of anti-oxidation and scavenging free radicals, and reduce lipids. Mass peroxidation, the effect of improving memory ability

Inactive Publication Date: 2019-03-22
津药达仁堂集团股份有限公司达仁堂制药厂
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Problems solved by technology

Elderly cognitive impairment has a long course of disease, many pathogenic factors, complex pathological mechanisms and mutual influence, and the primary and secondary cause and effect are still unclear. Simply blocking a certain pathological process without taking into account others may not produce good therapeutic effects. Therefore, current clinical treatment Often several chemicals are administered at the same time
However, the effect of this treatment method is not ideal, and the side effects are relatively large

Method used

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  • Application of Qing dynasty palace longevity peach pill in preparation of drugs for treating and alleviating memory loss, amnesia and cognitive disorder
  • Application of Qing dynasty palace longevity peach pill in preparation of drugs for treating and alleviating memory loss, amnesia and cognitive disorder
  • Application of Qing dynasty palace longevity peach pill in preparation of drugs for treating and alleviating memory loss, amnesia and cognitive disorder

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0052] 1 Effect and mechanism of Qinggong Shoutao Pill on learning and memory ability of naturally aging mice

[0053] 1.1 Drugs and reagents

[0054] Coarse powder of raw material medicine of Qinggong Shoutao Pills, provided by Tianjin Zhongxin Pharmaceutical Industry Darentang Pharmaceutical Factory, batch number: P004; Ginkgo biloba extract tablets (standard Ginkgo biloba extract EGb761, trade name: Ginato), Germany Weimar Shupei Doctor Pharmaceutical Factory, batch number: 4181212; Donepezil (Aricept): 10 mg, manufactured by Peizer PGM in France, and repackaged by Eisai (China) Pharmaceutical Co., Ltd. The dosage is based on the clinical and experimental literature reports and the results of previous experiments in our laboratory.

[0055] ACh, AChE enzyme-linked immunoassay kit: Nanjing Jiancheng Institute of Bioengineering, batch number: 20150625, 20151023; MDA, SOD, protein content assay kit: Nanjing Jiancheng Institute of Bioengineering, batch number: 20150707, 201507...

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Abstract

The invention provides application of Qing dynasty palace longevity peach pill in the preparation of drugs for treating and alleviating memory loss, amnesia and cognitive disorder, which belongs to the technical field of traditional Chinese medicines. By means of three types of geriatric cognitive disorder-imitated animal models, i.e. naturally aged mice, APP / PS1 double-transgenic mice and SAMP8 senescence-accelerated mice, the invention adopts techniques and methods of a Morris water maze, ELISA (enzyme-linked immuno sorbent assay), HE staining and the like to observe the effect and mechanismof the Qing dynasty palace longevity peach pill in intervening with learning memory from the aspects of ethology, central neurotransmitters, related enzyme and other biochemical indexes, histomorphology, cytomorphology and the like.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to the new application of Qinggong Shoutao Pills for improving memory loss, amnesia and cognitive impairment. Background technique [0002] Aging is a definite risk factor for cognitive impairment in the elderly. The prevalence of cognitive impairment in the elderly tends to increase with age. Elderly cognitive impairment has a long course of disease, many pathogenic factors, complex pathological mechanisms and mutual influence, and the primary and secondary causes and effects are unclear. Simply blocking a certain pathological process without taking into account others may not produce good therapeutic effects. Therefore, current clinical treatment Often several chemicals are used simultaneously. However, the effect of this treatment method is not ideal, and the side effects are relatively large. Contents of the invention [0003] In view of this, the pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61K9/20A61P25/00A61K35/48A61K35/64
CPCA61K9/20A61K35/48A61K35/64A61K36/232A61K36/258A61K36/52A61K36/725A61K36/804A61K36/815A61K36/8965A61K36/8968A61K36/9062A61K2300/00
Inventor 刘遵利丛伟红徐晨霞王强袁婷婷陈明欣付涵煦王昕
Owner 津药达仁堂集团股份有限公司达仁堂制药厂
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