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Device for preparing caspofungin acetate for injection

A technology of caspofungin acetate and injection, which is applied in the direction of making drugs into special physical or ingestible devices, peptide preparation methods, and cyclic peptide components, which can solve the problems of solvent residues, poor product stability, Improve costs and other issues to achieve the effect of reducing heating time and energy consumption, improving stability and avoiding waste

Inactive Publication Date: 2019-03-26
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, methanol, ethanol, ethyl acetate, tetrahydrofuran, isopropanol, acetonitrile and other solvents are usually used in the preparation process of existing caspofungin acetate, and the purification is difficult, so the solvent in the prepared caspofungin acetate finished product The content is usually difficult to meet the relevant regulations on solvent residues. At the same time, the resulting product has poor stability and needs to be stored at low temperature, which increases the cost of transportation and storage of the finished product of caspofungin acetate

Method used

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  • Device for preparing caspofungin acetate for injection
  • Device for preparing caspofungin acetate for injection

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Effect test

Embodiment 1

[0039] like figure 1 , 2 As shown, the present invention is used for the device of caspofungin acetate preparation for injection, comprises drying tower 1, and drying tower 1 comprises bottom plate 11, side plate 12 and top plate 13, and top plate 13 is provided with several atomizing nozzles 2, atomizing nozzles 2 through the top plate 13 towards the bottom plate 11, the top of the atomizing nozzle 2 is connected to a liquid storage tank 22 for storing caspofungin acetate solution through a conduit 21, and an air nozzle 3 is arranged on the side plate 12 of the drying tower 1, The gas nozzle 3 is connected with a helium storage tank 32 through an air duct 31 .

[0040] The top plate 13 of the drying tower 1 is provided with an air extraction pipe 4, and the air extraction pipe 4 is connected with the first vacuum pump 41, and the other end of the first vacuum pump 41 is connected with a gas-liquid separation device 43 through a pipeline one 42, and the discharge of the gas-l...

Embodiment 2

[0047] like figure 1 , 2 As shown, the present invention is used for the device of caspofungin acetate preparation for injection, comprises drying tower 1, and drying tower 1 comprises bottom plate 11, side plate 12 and top plate 13, and top plate 13 is provided with several atomizing nozzles 2, atomizing nozzles 2 through the top plate 13 towards the bottom plate 11, the top of the atomizing nozzle 2 is connected to a liquid storage tank 22 for storing caspofungin acetate solution through a conduit 21, and an air nozzle 3 is arranged on the side plate 12 of the drying tower 1, The gas nozzle 3 is connected with a helium storage tank 32 through an air duct 31 .

[0048] The top plate 13 of the drying tower 1 is provided with an air extraction pipe 4, and the air extraction pipe 4 is connected with the first vacuum pump 41, and the other end of the first vacuum pump 41 is connected with a gas-liquid separation device 43 through a pipeline one 42, and the discharge of the gas-l...

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Abstract

The invention discloses a device for preparing caspofungin acetate for injection, comprising a drying tower. The drying tower comprises a bottom plate, a side plate and a top plate. The top plate is provided with a plurality of atomizing nozzles. The atomizing nozzles pass through the top plate toward the bottom plate. The tops of the atomizing nozzles are connected through a guide pipe to a reservoir for storing a caspofungin acetate solution. The side plate of the drying tower is provided with an air nozzle. The air nozzle is connected to a helium storage tank through an air guiding pipe. The device can effectively improve the purity of the prepared caspofungin acetate for injection, thereby avoiding the degradation of caspofungin acetate and improving the stability of the product.

Description

technical field [0001] The invention relates to the field of pharmaceutical manufacturing, in particular to a device for preparing caspofungin acetate for injection. Background technique [0002] Caspofungin acetate for injection can be used for empiric treatment of neutropenia, suspicious fungal infection in patients with fever, and invasive aspergillosis that is ineffective or intolerable to other treatments. Caspofungin is effective against Aspergillus (including Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, A. Candida, Candida gillimont, Candida kactii, Candida krusei, Candida lipolytica, Candida portuguese, Candida parapsilosis, Candida plicata, and Tropicale) with in vitro activity, caspofen acetate Net can inhibit the synthesis of β(1,3)-D-glucan in the cell wall of many filamentous fungi and yeasts, thereby inhibiting the reproduction of pathogenic bacteria, and there is no P(1,3)-D-glucan in mammalian cells Polysaccharides, so the side effects on t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/56C07K1/14A61J3/00A61K38/12A61K9/16A61P31/10
CPCC07K7/56A61J3/00A61K9/0019A61K9/16A61K38/12A61P31/10
Inventor 张静文周燕伟高天睿
Owner SICHUAN PHARMA
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