Ascorbic acid and chitooligosaccharide composite salt, and preparation method and application thereof

A technology of ascorbic acid and chitosan oligosaccharide, applied in the application, antidote, pharmaceutical formulation and other directions, can solve the problems of unstable chitosan oligosaccharide, easy discoloration, unacceptable, etc., to solve the problem of solubility, strong synergistic physiological function, enhance The effect of immunity

Inactive Publication Date: 2019-03-29
QINGDAO BZ OLIGO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, domestic industrialized methods for preparing chitosan oligosaccharides mainly use chemical methods, physical methods, enzymatic degradation, etc. All preparation methods need to dissolve chitosan raw materials in weak acid solutions such as acetic acid, lactic acid, citric acid, or dilute hydrochloric acid. and dilute sulfuric acid, and then degrade, and the resulting product is filtered and separated, and then spray-dried or freeze-dr

Method used

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  • Ascorbic acid and chitooligosaccharide composite salt, and preparation method and application thereof
  • Ascorbic acid and chitooligosaccharide composite salt, and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0022] The preparation method of the ascorbic acid chitosan oligosaccharide compound salt provided by the present invention comprises the following steps: first dissolving the chitosan oligosaccharide in pure water according to a ratio of 3%, and mixing it with ascorbic acid according to the ratio of 1:1 according to the total amount of amino groups of the chitosan oligosaccharide , the mixed solution was stirred at 25°C for 2 hours, the reaction solution was decolorized by activated carbon, and then alcohol was added under stirring at room temperature for centrifugation, sedimentation, washing, and drying to obtain ascorbic acid chitosan oligosaccharide compound salt. The preparation method can also obtain different Ascorbic acid chitosan oligosaccharide compound salt of molecular weight segment grade.

Embodiment 2

[0024] The preparation method of the ascorbic acid chitosan oligosaccharide compound salt provided by the present invention comprises the following steps: first dissolving the chitosan oligosaccharide in pure water according to a ratio of 5%, and mixing it with ascorbic acid according to the ratio of 1:1 according to the total amount of amino groups of the chitosan oligosaccharide , the mixed solution was stirred at 50°C for 2 hours, the reaction solution was decolorized by activated carbon, and then alcohol was added under stirring at room temperature for centrifugation, sedimentation, washing, and drying to obtain ascorbic acid chitosan oligosaccharide compound salt. The preparation method can also obtain different Ascorbic acid chitosan oligosaccharide compound salt of molecular weight segment grade.

Embodiment 3

[0026] The preparation method of the ascorbic acid chitosan oligosaccharide compound salt provided by the present invention comprises the following steps: first dissolving the chitosan oligosaccharide in pure water according to a ratio of 3%, and mixing it with ascorbic acid according to the ratio of 1:2 according to the total amount of amino groups of the chitosan oligosaccharide , the mixed solution was stirred at 100°C for 2 hours, the reaction solution was decolorized by activated carbon, and then alcohol was added under stirring at room temperature for centrifugation, sedimentation, washing, and drying to obtain ascorbic acid chitosan oligosaccharide compound salt. The preparation method can also obtain different Ascorbic acid chitosan oligosaccharide compound salt of molecular weight segment grade.

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Abstract

The invention discloses an ascorbic acid and chitooligosaccharide composite salt, and a preparation method and an application thereof. The preparation method of the ascorbic acid and chitooligosaccharide composite salt comprises the following steps: dissolving 1-10% of chitooligosaccharide in pure water, mixing the obtained solution with ascorbic acid according to a ratio of the total amount of amino groups in the chitooligosaccharide to the amount of the ascorbic acid of 1:(0.1-5), stirring the obtained mixed solution at 15-150 DEG C for 1-5 h, decolorizing the obtained reaction solution withactivated carbon, adding an alcohol while stirring at normal temperature, and carrying out centrifugation, sedimentation, washing and drying to obtain the ascorbic acid and chitooligosaccharide composite salt. The ascorbic acid and chitooligosaccharide composite salt with different molecular weight grades also can be obtained through the preparation method of the ascorbic acid and chitooligosaccharide composite salt; and the ascorbic acid and chitooligosaccharide composite salt obtained by the method has good water solubility and excellent biological activity, and can be widely used in fieldsof foods, functional additives and the like.

Description

technical field [0001] The invention relates to a compound salt and its preparation method and application, in particular to an ascorbic acid chitooligosaccharide compound salt and its preparation method and its application in the field of food functional additives, belonging to the technical field of food additives. Background technique [0002] Ascorbic acid, also known as vitamin C, is an acidic polyhydroxy compound containing 6 carbon atoms with the molecular formula C 6 h 8 o 6 , the molecular weight is 176.1. Its structure is similar to glucose, and the two adjacent enol hydroxyl groups at the 2nd and 3rd positions in the molecule are easily dissociated to release H + , So it has the nature of acid, called ascorbic acid. Ascorbic acid has a strong reducing property and is easily oxidized into dehydroascorbic acid, but the reaction is reversible, and ascorbic acid and dehydroascorbic acid have the same physiological function, but if dehydroascorbic acid continues to...

Claims

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Application Information

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IPC IPC(8): C08B37/08C07D307/62A23L33/10A61K31/375A61K31/722A61P1/16A61P3/04A61P3/06A61P9/12A61P37/04A61P39/00A61P39/02A23L33/125A23L33/15
CPCA23L33/10A23L33/125A23L33/15A23V2002/00A61K31/375A61K31/722A61P1/16A61P3/04A61P3/06A61P9/12A61P37/04A61P39/00A61P39/02C07D307/62C08B37/003A23V2200/30A23V2200/32A23V2200/324A23V2200/326A23V2200/3262A23V2200/332A61K2300/00
Inventor 徐小龙张斌管昶王丽丽
Owner QINGDAO BZ OLIGO BIOTECH
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