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A construction method and application of UPLC fingerprint of Morus alba medicinal material

A technology of fingerprint spectrum and construction method, applied in the field of drug analysis and drug quality control, can solve the problems of chemical composition index evaluation of Morus alba medicinal material, cannot fully reflect the quality of the medicinal material, etc., achieves simple pretreatment operation, improves reproducibility Sexual, method simple effect

Active Publication Date: 2021-11-30
GUANGDONG YIFANG PHARMA
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  • Abstract
  • Description
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Problems solved by technology

[0003] At present, there are few literature reports on the fingerprint or characteristic map of Cortex Morus alba. The 2015 edition of "Chinese Pharmacopoeia" only includes traits, microscopic identification and TLC identification, and there is no clear chemical composition index to evaluate the medicinal material of Cortex Morus alba. The quality of medicinal materials, simply measuring the amount of one or several effective (index) ingredients can no longer fully reflect the quality of medicinal materials

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  • A construction method and application of UPLC fingerprint of Morus alba medicinal material
  • A construction method and application of UPLC fingerprint of Morus alba medicinal material
  • A construction method and application of UPLC fingerprint of Morus alba medicinal material

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Embodiment Construction

[0027] The present invention will be further described below through specific embodiments. The following examples are specific embodiments of the present invention, but the embodiments of the present invention are not limited by the following examples.

[0028] 1. Instruments and reagents

[0029] 1.1 Instrument

[0030] Instruments: Waters high-performance liquid chromatography (H-Class, Waters Corporation); ME204E one-millionth analytical balance (Mettler-Toledo); XP26 millionth analytical balance (Mettler -Toledo); KQ500D CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); HWS28 constant temperature water bath (Shanghai Yiheng Technology Co., Ltd.); Milli-Q Direct ultrapure water system (Merck Co., Ltd.) .

[0031] 1.2 Reference substances and reagents

[0032] Mulberry A reference substance (batch number: 17071002, Chengdu Pufeide Biotechnology Co., Ltd., purity>98%); acetonitrile and phosphoric acid were chromatographically pure; water was ultrapure water...

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Abstract

The invention discloses a method for constructing a UPLC fingerprint of Morus alba medicinal material and its application, comprising the steps of: preparation of a reference substance solution, preparation of a test solution, ultra-high phase liquid chromatography determination, establishment of a fingerprint, similar degree evaluation and cluster analysis. The present invention establishes a UPLC fingerprint method for rapid identification of Morus alba medicinal material within 23 minutes, and performs similarity evaluation and cluster analysis on the data. The quality of white skin medicinal materials provides a basis.

Description

technical field [0001] The invention belongs to the technical field of drug analysis and drug quality control, and in particular relates to a method for constructing a fingerprint of Cortex Mori medicinal material and its application. Background technique [0002] Morus alba, also known as mulberry root bark or white mulberry bark, is the dry root bark of the Moraceae plant Morus alba L. It was first recorded in "Shen Nong's Materia Medica", and its nature and flavor are sweet and cold, and it belongs to the lung meridian. It is used for asthma and cough due to lung heat, edema, fullness, oliguria, and edema of the face and skin. Modern research shows that the chemical composition of Morus alba mainly contains flavonoids, phenolic acids, alkaloids and other components; flavonoids mainly include: morin, morin, albanin C, D; Phenolic acid compounds are mainly three types of stilbenes, 2-phenylbenzofurans and stilbene oligomers, mainly including resveratrol, oxidized resverat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/86
CPCG01N30/02G01N30/8686
Inventor 曹斯琼李振雨李国卫王利伟索彩仙李乐何民友潘礼业陈向东
Owner GUANGDONG YIFANG PHARMA