Multi-beam optical coherent elastic measurement system and method based on microlens array
A microlens array and optical coherence technology, applied in the field of biomedical elastic imaging, can solve the problems of large phase error of frequency-sweeping OCT, unsuccessful application of human cornea measurement, and high-speed frequency-sweeping OCT is expensive, etc., to achieve rapid measurement Effect
Active Publication Date: 2021-06-29
FOSHAN UNIVERSITY
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Problems solved by technology
However, frequency-swept OCT still has a large phase error, and additional phase stabilization technology is required to obtain a stable phase
In addition, high-speed frequency-scanning OCT is expensive, and it is difficult to promote it clinically.
[0006] (2) The OCE scheme using line field (Line field) scanning (Liu etc. Biomedical OpticsExpress 7(8), 3021-3031(2016).) Although it can increase the detection speed of mechanical waves, it requires stronger light Strong signal, has not yet been successfully applied to the measurement of the human cornea
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[0026] combine figure 1 , figure 2 , image 3 , Figure 4 with Figure 5 , the present embodiment provides a multi-detection beam optical coherence measurement system based on a microlens array, including an OCT detection subsystem and a load excitation subsystem 2, and the OCT detection subsystem includes a wide-spectrum light source 11, a first fiber coupler 12. A second fiber optic coupler group 13, a sample arm group 14, a reference arm group 15, and a spectrum detector group 16 composed of a plurality of fiber optic couplers, wherein the wide-spectrum light source 11 is connected to the first fiber optic coupler 12 One end, the other end of the first fiber coupler 12 is connected to one end of the second fiber coupler group 13, and one end of the second fiber coupler group 13 is also connected to a spectral detector group 16, and the second optical fiber The other end of the coupler group is respectively connected to the reference arm group 15 and the sample arm grou...
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The invention provides a multi-beam optical coherent elasticity measurement system and method based on a microlens array. The cornea positioning subsystem is used to locate the excitation and measurement position of the cornea, and the cornea excitation subsystem is used to generate a small amount of mechanical waves and deformation of the cornea. Through OCT The detection subsystem detects the mechanical wave and deformation of each sampling point with high precision, and realizes the rapid measurement of corneal elastic parameters. The OCT detection subsystem includes a wide-spectrum light source, a first fiber coupler, a second fiber coupler group, a sample arm, a reference arm group, and a spectrum detector group, and each optical path of the sample arm is provided with a collimator that cooperates with each other. Mirrors and cylinder lenses, each optical path is also provided with a microlens array at the front of the cornea. The patent of the present invention uses a microarray lens as the key optical element, without the need to use the galvanometer scanning method like the traditional OCE, and without rotating the sample arm, it can simultaneously measure the multi-directional and multi-position elasticity around the sample excitation point under a single load excitation response.
Description
technical field [0001] The patent of the present invention relates to the field of biomedical elastography, in particular to a microlens array-based multi-beam optical coherent in vivo corneal elastometric measurement system and method. Background technique [0002] The human cornea is the main refractive medium of the human eye. The elastic mechanical characteristics of the cornea play an important role in maintaining the normal structure and function of the cornea, and are an important basis for studying the physiological and pathological characteristics of the cornea. Corneal diseases (such as keratoconus, corneal ectasia) and corneal surgery (corneal refractive surgery, ultraviolet cross-linking CXL, etc.) can cause changes in the elastic mechanical properties of the cornea. Conventional clinical detection methods are used for diagnosis based on corneal morphology (topography, thickness, curvature, etc.) and intraocular pressure parameters; although the detection rate of...
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IPC IPC(8): A61B3/10
CPCA61B3/10
Inventor 蓝公仆陈国杰许景江安林黄燕平秦嘉谭海曙
Owner FOSHAN UNIVERSITY