Preparation method for medical anti-bacterial and anti-adhesion gauze bandage for burn

A technology of gauze and bandages, applied in bandages, medical science, absorbent pads, etc., can solve problems affecting thrombus formation, blood compatibility reduction, etc., and achieve the effect of accelerated healing, convenient operation, and good stability

Inactive Publication Date: 2019-04-19
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the blood contacts the material, the plasma protein will be adsorbed to the surface of the material in less than 1 second to form a protein adsorption layer, which will cause the adsorption of a large number of platelets, thereby indirectly affecting the formation of thrombus, resulting in a decrease in the blood compatibility of the material

Method used

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  • Preparation method for medical anti-bacterial and anti-adhesion gauze bandage for burn
  • Preparation method for medical anti-bacterial and anti-adhesion gauze bandage for burn

Examples

Experimental program
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Effect test

Embodiment 1

[0021] A method for preparing a medical burn antibacterial and anti-adhesion gauze bandage. The ordinary bandage is used as the main structural material as the main component of the mechanical support. After the bandage is subjected to surface activation treatment, nano-sized zinc oxide (ZnO) is used as the inorganic filler and hydroxyl silicone oil. , low hydrogen-containing silicone oil, emulsifier I, emulsifier II, thickener and deionized hydration catalyst are mixed to form a zinc oxide silicone emulsion, and then the zinc oxide silicone emulsion is coated on the Prepared on activated gauze cloth, follow the steps below:

[0022] Add 10 parts by weight of nano-zinc oxide and 10 parts by weight of polymer microspheres to 50 parts by weight of hydroxyl silicone oil and 130 parts by weight of low-hydrogen silicone oil, raise the temperature to 140~160°C, and mix the above mixture evenly to form base paste 1. Put 5 parts by weight of the base cream into 1 part by weight of emu...

Embodiment 2

[0025] A kind of preparation method of medical burn antibacterial anti-adhesion type gauze bandage, similar to embodiment 1, according to the following steps:

[0026] Add 10 parts by weight of nano-zinc oxide and 10 parts by weight of polymer microspheres to 50 parts by weight of hydroxyl silicone oil and 130 parts by weight of low-hydrogen silicone oil, raise the temperature to 140~160°C, and mix the above mixture evenly to form base paste 1. Put 10 parts by weight of base cream into 2 parts by weight of emulsifier I (polyoxyethylene sorbitan fatty acid ester 80), 5 parts by weight of emulsifier II (sorbitan fatty acid ester 20) and 5 parts by weight of thickener agent (sodium polymethylcellulose), start stirring, slowly add 78 parts by weight of deionized water, stir evenly to obtain a silicone / zinc oxide emulsion product, finally add catalyst (dibutyltin dilaurate), and stir for 6 hours, Apply negative pressure to extract the dissolved air in the coating solution. After t...

Embodiment 3

[0028] A kind of preparation method of medical burn antibacterial anti-adhesion type gauze bandage, similar to embodiment 1, according to the following steps:

[0029] Add 10 parts by weight of nano-zinc oxide and 10 parts by weight of polymer microspheres to 50 parts by weight of hydroxyl silicone oil and 130 parts by weight of low-hydrogen silicone oil, raise the temperature to 140~160°C, and mix the above mixture evenly to form base paste 1. Put 20 parts by weight of the base cream into 4 parts by weight of emulsifier I (polyoxyethylene sorbitan fatty acid ester 80), 10 parts by weight of emulsifier II (sorbitan fatty acid ester 20) and 10 parts by weight of thickener agent (sodium polymethylcellulose), start stirring, slowly add 56 parts by weight of deionized water, and stir evenly to obtain a silicone / zinc oxide emulsion product, finally add catalyst (dibutyltin dilaurate), and stir for 6 hours, Apply negative pressure to extract the dissolved air in the coating solution...

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Abstract

The invention relates to a gauze bandage material used in surgery and wound dressing, and belongs to the application field of preparation and processing of medical devices. The preparation method comprises the following steps that an ordinary bandage as a main structural material is used as a main component of a mechanical support, after being subjected to surface activation, a nanometer zinc oxide (ZnO) material as inorganic filler is mixed with hydroxyl silicone oil, low-hydro silicone oil, an emulsifier I, an emulsifier II, a thickening agent, deionized water and a catalyst to form a zinc oxide organic silicone emulsion, and the activated gauze material is coated with the zinc oxide organic silicone emulsion by using an impregnation method or a machine coating method to obtain the medical anti-bacterial and anti-adhesion type gauze bandage. The preparation method has the advantages that the operation is convenient, postoperative healing is accelerated, the stability is high, the bandage is firm and not likely to fall off, protein adhesion is not generated, and the bandage has an anti-bacterial property.

Description

technical field [0001] The invention relates to a gauze bandage material used in surgery and wound dressing, belongs to the application field of medical device preparation and processing, and relates to a preparation method of a medical burn antibacterial and anti-adhesion gauze bandage. technical background [0002] Bandage materials are usually used in first aid and postoperative wound healing operations, which can provide a clean and moist microscopic environment for the wound, provide physical support, and protect the wound surface. The new wound protection bandage is characterized by the use of anti-biosorption materials as anti-adhesive bandages base material used. The main challenge is the adsorption of non-specific proteins on the material surface. When blood comes into contact with the material, plasma protein will adsorb to the surface of the material in less than 1 second to form a protein adsorption layer, which will cause the adsorption of a large number of pla...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/20A61L15/18A61L15/42A61L15/44A61L15/46
CPCA61L15/28A61L15/18A61L15/20A61L15/26A61L15/42A61L15/44A61L15/46A61L2300/102A61L2300/404C08L1/02C08L83/04
Inventor 何丹农严一楠王杰琳杨迪诚王萍徐艳金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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