Chute plate device for studying influences of fluid shear stress on cells and measuring method

Abstract

The invention discloses a chute plate device for studying the influences of fluid shear stress on cells and a measuring method. The chute plate device comprises a box shell (1) for containing cell carriers, an input pipe (5) arranged on the box shell (1) and used for injecting flowing fluid for generating shear stress on the cells into the box shell (1), an output pipe (6) arranged on the box shell (1) and used for discharging the flowing fluid for generating shear stress on the cells out of the box shell (1), and a signal picking sensor (7) arranged on the output pipe (6) and used for pickingsignals of the shear stress acting on the cells. The cell carriers are contained in the box shell (1), the flowing fluid for generating the shear stress on the cells is generated through the input pipe (5) and the output pipe (6), the signals of the shear stress acting on the cells are picked by the signal picking sensor (7), a flat plate with a groove is not used any more, and therefore the precision of the influences of the fluid shear stress on the cells is improved.

Description

technical field [0001] The invention relates to a chute plate device and a measurement method, in particular to a chute plate device and a measurement method for studying the influence of fluid shear stress on cells. Background technique [0002] Studying the influence of fluid shear stress on cell morphology and function is an important research topic for cells. In the existing chute plate devices and measurement methods used to study the influence of fluid shear stress on cells, conventional chute plates are used. That is, a single flat plate tank, the steps are: the cells are seeded on the glass slide first, put into the flat plate groove, the liquid flows in from one end of the chute plate, passes through the plate, and flows out from the other end, according to the shape of the stressed cells and Functional changes to determine the effects of fluid shear stress on cells. Calculate the magnitude of the fluid shear stress generated according to the velocity and amount of...

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Problems solved by technology

[0004] 1. It is limited to a single type of cell and cannot be applied to the interaction of two different cells. Under the condition of fluid shear stress, the interaction between cells (cross talk) is a normal state in the body. Since there is no Corresponding instruments and equipment are used to study the interaction between cells. At present, the interaction between cells is only in a static state, and it is impossible to realize the interaction between two different cells under the condition of fluid shear stress.

[0005] 2. For the conventional chute plate used, the fluid shear stress cannot be precisely controlled. The fluid shear stress generated is only calculated according to the velocity and amount of the outflow liquid, which is not conducive to force control or experimental results. repeat

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