9 results about "Fluid shear stress" patented technology

This application discloses an adaptive oscillation method, system, and storage medium for blood products. The method includes: S1: acquiring and reconstructing multidimensional physical features of the blood bag surface to obtain three-dimensional morphological data and heat distribution data of the blood bag surface; S2: based on the three-dimensional morphological data and heat distribution data, using a fluid dynamics proxy model to inversely deduce the fluid shear stress and comprehensive physical suspension feature vector of the blood inside the blood bag, and performing cross-calibration on both, continuously outputting a mixed completion confidence score; S3: adjusting the motion parameters of the oscillation tray and clamping mechanism in real time according to the mixed completion confidence score, and stopping oscillation when the mixed completion confidence score continuously exceeds a preset threshold. This application achieves real-time, non-invasive sensing of the blood state inside a sealed blood bag, ensuring uniform suspension of red blood cells while avoiding mechanical hemolysis, significantly improving the safety, adaptability, and processing efficiency of blood product oscillation processing.

The invention provides an automatic kitchen waste treatment method based on multistage heat exchange, which comprises the following steps: acquiring solid-phase particle density distribution of a kitchen waste input flow, recording a particle settling velocity fluctuation value, and predicting solid-phase content change based on the solid-phase particle density distribution and the particle settling velocity fluctuation value; according to the distribution state of the pressure difference in the centrifugal cylinder, the adjusting direction and the adjusting amplitude of the rotating speed gradient are determined according to the mapping relation between the pressure difference distribution and the rotating speed gradient, the force field rotating inertia is dynamically updated, and centrifugal field distribution is obtained; according to the real-time change of the solid-liquid interfacial tension, the output power of the heating module is adjusted, the optimal value of the interfacial tension gradient is determined, and phase state layering is obtained; and calculating fluid shear stress required by a subsequent thermal separation stage based on fluid turbulent flow distribution and a separation purity value of a mixed region, and determining power distribution parameters of thermal separation by combining with a separation purity value of a centrifugal separation stage.

The present invention relates to isolated nucleic acid molecules, comprising a functional mammalian EGR-1 (early growth response protein 1) promoter region that is operatively linked to a gene encoding a fluorescent protein and controls expression of said gene. The present invention further relates to nucleic acid vectors, comprising said nucleic, cells comprising said nucleic acids or vectors, being capable of sensing and indicating fluid shear stress acting on themselves, and methods of generating the same. Furthermore, the present invention relates to methods of evaluating fluid shear stress acting on cells in real-time during the operation of a biotechnological device or system, methods of evaluating a biotechnological device or system with respect to fluid shear stress acting on cells caused by operation of said device or system, and methods of designing a biotechnological device or system, said methods using said cells.

The invention discloses a gear gluing fault diagnosis method under a friction dynamics coupling condition and a related device, and relates to the technical field of gear gluing fault diagnosis, and the method comprises the steps: carrying out the iterative calculation based on a dynamics model in a gear transmission process under the friction dynamics coupling condition, fluid shear stress in the gear transmission process is obtained, the contact surface heat distribution coefficient of the driving gear and the contact surface heat distribution coefficient of the driven gear are obtained through calculation based on the fluid shear stress, and the contact surface temperature of the driving gear and the contact surface temperature of the driven gear are further obtained through calculation; and further calculating to obtain a gluing safety coefficient of the driving gear and a gluing safety coefficient of the driven gear, and based on the gluing safety coefficient of the driving gear and the gluing safety coefficient of the driven gear, determining whether a gear gluing fault exists in the transmission process of the driving gear and the driven gear so as to complete gear gluing fault diagnosis. The diagnosis precision and the application range of gear gluing fault diagnosis can be improved.

The invention relates to the technical field of spectral analysis, in particular to a spectral data analysis method and system for water pollutant identification and a medium. The method comprises the following steps: acquiring flow velocity gradient data and a multi-depth spectral signal sequence, extracting a pollutant feature vector after adaptive filtering, and calculating vertical gradient distribution; on the basis, the initial boundary of the pollutant block mass is determined by adopting spatial clustering, and optimization is carried out by combining the turbulence pulsation frequency and the fluid shear stress direction. And determining a diffusion path according to the optimized boundary, and correcting the contour boundary by using the particle suspension density distribution. And a self-adaptive data updating mechanism is triggered by evaluating the matching degree of the corrected boundary and the flow field characteristics. And finally, fusing multi-source data to generate a three-dimensional pollutant contour recognition result. According to the method, the influence of turbulence interference and flow field deviation is effectively overcome, and high-precision identification and tracking of the three-dimensional diffusion form of the pollutants in a complex water flow environment are realized.

The application belongs to the technical field of biology, and discloses a culture method for large-scale human kidney organoids. The application discloses a culture method for large-scale kidney organoids, which comprises the following steps: using a culture solution to induce culture of stem cells to generate developing organoids; applying fluid shear stress to the developing organoids for culture, i.e. obtaining kidney organoids; the method for applying fluid shear stress comprises placing the developing organoids in a fluid perfusion system, adjusting the fluid flow rate, and making the fluid shear force be 0.02-0.3 dyn / cm 2 , or stirring or rotating a culture system containing the developing organoids. The culture method provided by the application can significantly promote targeted enrichment and maturation of distal renal units, greatly improves the physiological fidelity of the organoids, successfully remodels the metabolic microenvironment, breaks through the glycolysis development bottleneck, and realizes large-scale preparation with high molding rate and high uniformity.

Described herein are methods for producing organoids at a large scale sufficient for tissue biomanufacturing that include combining cells and architected matrix microcarriers into a suspension in a stirred-tank (STR) bioreactor comprising culture medium. The method further includes culturing the cells and the matrix microcarriers and exposing the cells and the microcarriers to the fluidic shear stress (FSS) in the STR bioreactor to induce differentiation and / or maturation of the cells, and / or functional integration of the cells with other types of cells, if present in the STR. Described herein are also organoids and tissues produced by the described methods and their uses.

This method for producing vascular endothelial cells derived from pluripotent stem cells comprises: a preparation step for preparing vascular endothelial progenitor cells derived from pluripotent stem cells; and a stress application step for applying a fluid shear stress to the vascular endothelial progenitor cells.

The invention discloses a skeletal structure evolution method and system driven by fluid shear stress, and belongs to the technical field of biomechanics and computational bionics. The method comprises the following steps: S1, reading an initial geometric model of a skeleton, and automatically identifying mechanical boundary features of the model; s2, applying displacement constraint on the fixed constraint surface, and defining a unit on the surface as a remodeling exclusion area; s3, performing fluid-solid coupling analysis on the skeleton model by adopting an explicit kinetic analysis method, and outputting fluid shear force; s4, based on the fluid shear force of each surface unit extracted in S3, calculating the average fluid shear force of each outer surface unit except the remodeling exclusion area, setting a reference stress value, and simulating bone absorption and deposition; s5, based on a mechanical field obtained by mechanical analysis, identifying a unit addition area and a unit deletion area; and S6, repeatedly executing the steps S3-S5 until a preset number of iterations or a convergence standard is reached, so that the skeleton geometric structure is evolved to reach a relatively stable state in a new mechanical environment.