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Toothpaste containing chitobiose and preparation method of toothpaste

A technology for chitobiose and toothpaste is applied in the field of toothpaste containing chitobiose and its preparation, which can solve the problems of complex preparation process, influence of toothpaste taste and high cost, and achieves simplified preparation process, excellent appearance quality and low production cost Effect

Pending Publication Date: 2019-04-23
天垚生命科学(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if chitosan, which is insoluble in anyone, is used as an antibacterial agent in toothpaste, an acidic solvent must be used, because the antibacterial activity of chitosan can only be reflected when it is in a dissolved state. Acetic acid is the best solvent choice, but acetic acid will The mouthfeel of toothpaste is affected, therefore, it is often necessary to add other additives for adjustment, making the preparation process complicated and costly, and toothpaste containing chitosan is rarely used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Present embodiment provides a kind of toothpaste containing chitobiose, friction agent is silicon dioxide, thickener is carboxymethyl cellulose, excipient is glycerin and sorbitol, sweetener is saccharin, anionic surfactant Sodium lauryl sulfonate. Calculated by mass percentage, the ratio of the main components is: 1% chitobiose, 25% silicon dioxide, 1.0% carboxymethyl cellulose, 5% glycerin, 55% sorbitol, 0.5% flavor , 0.2% saccharin, 2% sodium lauryl sulfonate and 10.3% deionized water.

[0022] The toothpaste preparation method that present embodiment contains chitobiose comprises the following steps:

[0023] S1, using deionized water to dissolve chitobiose and saccharin to obtain solution A;

[0024] S2. Put the solution A in S1 into the paste-making device, and pump glycerin and sorbitol and stir evenly to obtain the mixture B;

[0025] S3. Turn on the agitator and scraper of the paste making device, and simultaneously add silicon dioxide, carboxymethyl cellulo...

Embodiment 2

[0028] The present embodiment provides a toothpaste containing chitobiose, the friction agent is silicon dioxide, the thickener is sodium carboxymethyl cellulose, the excipients are glycerin and sorbitol, the sweetener is saccharin, and the anionic surface active The agent is sodium lauryl sulfonate. Calculated by mass percentage, the ratio of the main components is: 10% chitobiose, 20% silicon dioxide, 1.5% sodium carboxymethylcellulose, 5% glycerin, 50% sorbitol, 0.5% Flavor, 0.5% saccharin, 2% sodium lauryl sulfonate and 10.5% deionized water.

[0029] The toothpaste preparation method that present embodiment contains chitobiose comprises the following steps:

[0030] S1, using deionized water to dissolve chitobiose and saccharin to obtain solution A;

[0031] S2. Put the solution A in S1 into the paste-making device, and pump glycerin and sorbitol and stir evenly to obtain the mixture B;

[0032] S3. Turn on the agitator and scraper of the paste making device, and simul...

Embodiment 3

[0035] Present embodiment provides a kind of toothpaste containing chitobiose, friction agent is silicon dioxide, thickener is carboxymethyl cellulose, excipient is glycerin and sorbitol, sweetener is saccharin, anionic surfactant Sodium lauryl sulfonate. Calculated by mass percentage, the ratio of the main components is: 15% chitobiose, 15% silicon dioxide, 2.0% carboxymethyl cellulose, 5% glycerin, 50% sorbitol, 1.0% essence , 1.0% xylitol, 2% sodium lauryl sulfonate and 9% deionized water.

[0036] The toothpaste preparation method that present embodiment contains chitobiose comprises the following steps:

[0037] S1, using deionized water to dissolve chitobiose and xylitol to obtain solution A;

[0038] S2. Put the solution A in S1 into the paste-making device, and pump glycerin and sorbitol and stir evenly to obtain the mixture B;

[0039] S3. Turn on the agitator and scraper of the paste making device, and simultaneously add silicon dioxide, carboxymethyl cellulose an...

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PUM

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Abstract

The invention provides toothpaste containing chitobiose. The water-soluble and edible chitobiose with strong antimicrobial properties are adopted as an antibacterial agent ingredient of the toothpasteto reduce the use of antibiotics. The toothpaste is prepared from, by mass, 0.5-15% of the chitobiose, 15-40% of a friction agent, 0.5-2% of a thickening agent, 1-2% of an anionic surfactant, 10-60%of an excipient, 0.1-1% of essence, 0.1-1% of a sweetener and 5-60% of deionized water. The invention further provides a preparation method of the toothpaste containing the chitobiose, which has the advantages that the preparation method is simple and practicable, the production cost is lower, and the prepared toothpaste is stable in performance and good in quality.

Description

technical field [0001] The invention relates to a toothpaste and a preparation method thereof, in particular to a chitobiose-containing toothpaste and a preparation method thereof. Background technique [0002] Chitosan is a natural polymer substance containing amino polysaccharides, which is widely found in the nails of marine organisms such as shrimp and crabs. [0003] In the shell, it has broad-spectrum antibacterial properties. However, chitosan is insoluble in organic solvents and water, and only limitedly soluble in dilute acid solutions, thus limiting its application range. Oligochitosan is a degradation product of chitosan, which has a small molecular weight, is easily soluble in water, and is easily absorbed by the human body or animals and plants. Therefore, oligochitosan has better physiological functions than chitosan, and experiments have proved that it also has a wide range of functions. Spectrum antibacterial properties. Chitobiose is a chitosan oligosacch...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61Q11/00A61P1/02A61P31/04A61P31/02
CPCA61Q11/00A61K8/60A61K2800/28
Inventor 杨国卫马文胜华长青徐洋黄新宇
Owner 天垚生命科学(深圳)有限公司
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