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Use of chlorogenic acid in the preparation of drugs for preventing or treating borderline tumors

A junctional, chlorogenic acid technology, applied in the field of biomedicine, achieves the effects of good clinical application prospects, improved prognosis and survival, and good tumor recurrence

Active Publication Date: 2021-05-04
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been reported that chlorogenic acid has a preventive or therapeutic effect on borderline tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Oral preparation prescription of the present invention

[0026] 1. Prescription 1

[0027] Chlorogenic acid 1000g.

[0028] Preparation method: aseptically weigh chlorogenic acid, and aseptically pack into powder.

[0029] 2. Prescription II

[0030] Chlorogenic acid 1000g, filler 500g, binder 5g.

[0031] Preparation method: Weigh chlorogenic acid, fillers, and binders according to the prescription, granulate, granulate, and pack into granules.

[0032] 3. Prescription Three

[0033] Chlorogenic acid 1000g, filler 5000g, binder 20g, lubricant 10g.

[0034] Preparation method: Weigh chlorogenic acid, filler and binder according to the prescription, granulate, granulate, add lubricant, compress into tablets to obtain tablets.

[0035] The above-mentioned filler is one or more of mannitol, lactose, starch, microcrystalline cellulose, and dextrin; the binder is sodium carboxymethyl cellulose, PVP; the lubricant is magnesium stearate, talcum powder, Micr...

Embodiment 2

[0036] Embodiment 2 injection preparation prescription of the present invention

[0037] 1. Prescription 1

[0038] Chlorogenic acid 1000g.

[0039] Preparation method (1): Aseptically weigh chlorogenic acid according to the prescription, and aseptically subpackage it into powder injection.

[0040] Preparation method (2): Weigh chlorogenic acid according to the prescription, dissolve in water for injection, filter and sterilize, fill, and freeze-dry to obtain freeze-dried powder injection.

[0041] 2. Prescription II

[0042] Chlorogenic acid 1000g, scaffold agent 2667g, antioxidant 67g.

[0043] Preparation method: Weigh chlorogenic acid, scaffolding agent, and antioxidant according to the prescription, dissolve in water for injection, filter and sterilize, fill, and freeze-dry to obtain freeze-dried powder injection.

[0044] The above-mentioned support agent is mannitol, lactose, and glucose; the antioxidant is sodium bisulfite, vitamins, glutathione, and folic acid. ...

Embodiment 3

[0045] Example 3 Inhibitory Effect of Chlorogenic Acid on Borderline Tumors

[0046] Get 1000g of chlorogenic acid, 300g of mannitol, 200g of lactose, and 5g of PVP, prepare granules according to prescription 2 in Example 1, and pack them into bags, 5g / bag. 3 times / day, 1 bag each time, take it orally with water on an empty stomach before meals, take continuously for 3 months as a course of treatment, and give 1 to 3 courses of treatment according to the patient's condition.

[0047]Patient 1, Liu, 35 years old, vaginal B-ultrasound showed a 36×52mm mass in the lower and inner side of the right ovary, with clear boundaries, papillary outside the capsule, slightly stronger echo, and rich blood flow information in the capsule. The obtained arterial blood flow spectrum was VP=29.3cm / Sri=0.67; a homogeneous mass with a size of about 15×16mm was found in the immediate vicinity of the mass, and the blood flow information was detected point-like in it, and the edge was petal-shaped. ...

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Abstract

The invention provides the use of chlorogenic acid in the preparation of medicines for preventing or treating borderline tumors. The present invention proves that chlorogenic acid has an obvious inhibitory effect on borderline tumors, especially ovarian borderline tumors, can effectively prevent and treat the implantation, metastasis and canceration of borderline tumors, and has a good inhibitory effect on postoperative tumor recurrence. It can effectively improve the prognosis and survival period of patients, and has a good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the use of chlorogenic acid in the preparation of drugs for preventing or treating borderline tumors. Background technique [0002] In 1973, WHO adopted the name "borderline malignant tumor" in the classification of ovarian tumors, and at the same time gave it the synonymous name "carcinoma of low malignant potential", making it an independent pathological type. The WHO classification published in 2003 named it a borderline tumor, a malignant ovarian epithelial tumor between benign tumors and cancer. Ovarian borderline tumors refer to active epithelial cell proliferation and nuclear atypia, increased mitotic phase, manifested as increased epithelial cell layers, but no stromal infiltration, and its histological characteristics and biological behavior are between benign and malignant epithelial ovarian tumors A subtype of tumors with no stromal invasion on histological exami...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61P35/00A61K35/04
CPCA61K31/216A61K35/04A61P35/00
Inventor 张洁黄望张飞
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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