Cherenkov event and gamma event coincidence imaging device and method

An imaging device and imaging method technology, applied in the fields of biomedical diagnostic systems, photoelectric signal processing and nuclear detection, can solve the problems of missing visible light data, etc., to resist the influence of biological tissue self-luminescence, reduce background noise, and improve imaging signal-to-noise ratio Effect

Inactive Publication Date: 2019-04-26
NANCHANG UNIV
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Problems solved by technology

Conventional PET only detects gamma photons annihilated by positrons, so part of the available visible light data is lost

Method used

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  • Cherenkov event and gamma event coincidence imaging device and method
  • Cherenkov event and gamma event coincidence imaging device and method
  • Cherenkov event and gamma event coincidence imaging device and method

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example 1

[0083] The parameters of data processing in this embodiment are listed here:

[0084] The actual device used in step (1) is a dark box with a size of 1.5m×1.5m×1.5m. The radiation source is 511keV positron annihilation gamma photon 18F-FDG. The red-enhanced silicon photomultiplier tube is used as the photosensitive element for Cherenkov photon detection. The scintillation detector of yttrium lutetium silicate / photomultiplier tube / blue-violet silicon photomultiplier tube is used as the gamma photon detection element, and the specific composition is as follows: Figure 7 As shown, the combination of detector units adopts a ring structure;

[0085] Step (2) using the angle (2-D), time (1-D), position (3-D), and energy (1-D) of the positron event as attribute values ​​to establish a two-particle likelihood function;

[0086] Step (3) the coincidence time is about 2ns, and the coincidence judgment adopts offline time coincidence processing, and the particle counting is gated;

...

example 2

[0091] The parameters for processing data in this application example 2 are listed here:

[0092] The actual device used in step (1) is to use a dark box with a size of 0.15m×0.15m×0.15m. The radiation source is 511keV positron annihilation gamma photon 18F-FDG. The red-enhanced silicon photomultiplier tube is used as the photosensitive element for Cherenkov photon detection. The scintillation detector of lanthanum bromide / blue-violet silicon photomultiplier tube is used as the gamma photon detection element, and the combination of detector units adopts a 12-plate structure ;

[0093] Step (2) using the angle (2-D), time (1-D), position (3-D), and energy (1-D) of the positron event as attribute values ​​to establish a two-particle likelihood function;

[0094] Step (3) the coincidence time is about 2ns, and the coincidence judgment adopts offline time coincidence processing, and the particle counting is gated;

[0095] Step (4) adopts the method of list data, without rearra...

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Abstract

The invention discloses a Cherenkov event and gamma event coincidence imaging device and method. In the prior art, in traditional positive electron emitting imaging, gamma photons annihilated by positive electrons are only detected, and part of visible light data capable of being obtained is lost. The Cherenkov event and gamma event coincidence imaging device comprises a rich-proton isotope injection module, a multi-radiation detector module, a multi-case time coincidence module, a system transfer function obtaining module and a nuclide distribution image reconstruction module, and the rich-proton isotope injection module is used for marking substances participating in physiological and biochemical processes in a living body, and is mainly used for shielding background light outside the living body and making the living body have luminous markers. The Cherenkov event and gamma event coincidence imaging device and method have the advantages that sensitivity is super high, more particleinformation can be mined, system precision and imaging quantitative accuracy are higher, and even time coincidence design resisting to background light and self illumination of the living body easilyreduces the background noise of imaging.

Description

technical field [0001] The invention relates to the fields of biomedical diagnosis system, photoelectric signal processing and nuclear detection, in particular to a Cherenkov event and Gamma event coincidence imaging device and method. Background technique [0002] Positron Emission Tomography (PET for short) is a new non-invasive medical imaging technology. PET is a non-invasive functional imaging, and it is one of the important imaging methods in the field of nuclear medicine and molecular imaging. In the early stages of disease, biochemical changes are often earlier than anatomical changes, and PET can dynamically and quantitatively measure pathophysiological changes and metabolic processes in humans or animals at the molecular level. By describing the position distribution and radioactivity changes of radiotracers in the body, it can non-invasively, quantitatively and dynamically evaluate the metabolic levels, biochemical reactions and functional activities of various o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01T1/161G01T1/29
CPCG01T1/161G01T1/2985
Inventor 邓贞宙邓玉姗韩春雷王玉皞刘志涛刘钰熊力伟段志文
Owner NANCHANG UNIV
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