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A detection method and application of traditional Chinese medicine composition

A detection method and composition technology, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of detection and monitoring of traditional Chinese medicine compositions, various flavors of traditional Chinese medicines, and inability to interfere with each other, so as to achieve effective quality performance, clear quality detection, and realize quality effect

Active Publication Date: 2022-04-26
BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Therefore, the technical problem to be solved by the present invention is to provide a detection method and application of a traditional Chinese medicine composition, which overcomes the inability to comprehensively and clearly detect the quality of the traditional Chinese medicine composition due to the various flavors of traditional Chinese medicine, complex components and mutual interference. To detect and monitor defects, improve the stability, consistency and controllability of the quality of the traditional Chinese medicine composition

Method used

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  • A detection method and application of traditional Chinese medicine composition
  • A detection method and application of traditional Chinese medicine composition
  • A detection method and application of traditional Chinese medicine composition

Examples

Experimental program
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Effect test

experiment example 1

[0064] Experimental Example 1 Ginsenoside Re and Ginsenoside Rg 1 Investigation of Gradient Elution Procedure in Content Determination

[0065] According to the composition and preparation method of Example 12, the granules obtained were divided into two groups in parallel, namely the test group and the control group. 1 content determination.

[0066] (1) Test group: get above-mentioned granule according to " preparation of need testing solution " method and " preparation of negative reference substance solution " method in embodiment 14, make need testing solution and negative reference substance solution, then according to implementation The disclosed "chromatographic condition" and "measurement method" of example 14 carry out the spectrum determination, and the results are as follows: figure 1 shown.

[0067] (2) Control group: get above-mentioned granule according to " the preparation of need testing solution " method and " the preparation of negative reference substanc...

experiment example 2

[0070] Experimental Example 2 Ginsenosides Re and Rg 1 Investigation on the preparation method of the test solution in the content determination

[0071]The granules obtained according to the composition of Example 12 and the preparation method are divided into three groups in parallel, respectively, the test group and the control group 1 and the control group 2, and each group has six parts, and the test group, the control group and the control group 2 are respectively as follows Methods Ginsenoside Re and Ginsenoside Rg 1 content determination.

[0072] (1) Test group: get above-mentioned granule according to " preparation of need testing solution " method and " preparation of negative reference substance solution " method in embodiment 14, make need testing solution and negative reference substance solution, then according to implementation The "chromatographic conditions" and "measurement methods" disclosed in Example 14 were used for spectrum determination.

[0073] (2...

experiment example 3

[0080] Experimental example 3 Investigation of the gradient elution procedure in the content determination of β-asarone and the identification of ligustilide

[0081] Due to the complexity of the ingredients in the traditional Chinese medicine composition of the present invention, most of which are flavonoids, saponins and polysaccharides, it is difficult to measure β-asarone and ligustilide. The effect of the desorption degree on the chromatographic analysis results.

[0082] According to the composition and preparation method of Example 12, the granules obtained were divided into two groups in parallel, namely the test group and the control group. 1 content determination.

[0083] (1) Test group: get above-mentioned granule according to " preparation of need testing solution " method and " preparation of negative reference substance solution " method in embodiment 17, make need testing solution and negative reference substance solution, then according to implementation The...

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Abstract

The invention provides a detection method of a traditional Chinese medicine composition, which comprises the following ingredients by weight: 4-9 parts of ginseng, 4-9 parts of fried jujube seed, 4-9 parts of roasted epimedium, rehmannia glutinosa 5-12 parts of Huang, 3-8 parts of Bran-fried Atractylodes Rhizome, 3-8 parts of Polygala, 4-9 parts of Shichangpu, 5-12 parts of Angelica, 1-5 parts of Zhilicorice, the detection method is based on octadecyl Silane bonded silica gel as filler; pure water as mobile phase A, acetonitrile as mobile phase B, gradient elution, detection wavelength: 198‑208nm; detection of ginsenoside Rg 1 , ginsenoside Re content determination, in addition, the HPLC method is also used to measure the content of the active ingredient β-asarone icariin in the composition, and the identification of Angelica sinensis, and the TLC method is used to achieve qualitative identification of Rehmannia glutinosa and Radix Glycyrrhizae in the prescription , the method of the present invention has high accuracy and sensitivity, wide detection range, and realizes effective control of drug quality, and can be used as a quality monitoring method for the traditional Chinese medicine composition and preparation.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a detection method and application of a traditional Chinese medicine composition. Background technique [0002] Alzheimer's disease (Alzheimerdisease, AD), also known as senile dementia, is a progressive and irreversible neurodegenerative disease. The disease is mainly clinically manifested by memory impairment, mental decline, executive dysfunction, and personality and behavior changes, and the onset is slow or insidious, and the incidence rate is high. It is more common in the elderly over 70 years old. The prevalence rate is 5% in the 65-year-old population, and as high as 40% in the 80-year-old population. The etiology of Alzheimer's disease is complex, which is generally the result of multiple factors such as genetic factors, environmental factors and living habits. [0003] The main clinical symptoms of dementia are progressive memory decline and c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/74
Inventor 李萍肖婷婷杨华张蓓高雯候譞
Owner BEIJING ZHONGYAN TONGRENTANG CHINESE MEDICINE R & D
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