Mechanical perfusion system for preservation of both isolated kidneys

An in vitro, mechanical technology, applied in the field of kidney transplantation, can solve the problem of the difficulty of multiple organ preservation and transportation in static cold preservation technology, and achieve the effect of alleviating renal reperfusion injury and ensuring renal life activity.

Active Publication Date: 2019-05-07
杭州莱普晟医疗科技有限公司
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] The invention provides a mechanical perfusion system for the preservation of isolated kidneys, which solves the problem of preservation and transportation of multiple organs that is difficult to solve in the existing static cold preservation technology

Method used

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  • Mechanical perfusion system for preservation of both isolated kidneys
  • Mechanical perfusion system for preservation of both isolated kidneys

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Embodiment Construction

[0040] like figure 1 Shown is the working state of a mechanical perfusion system for isolated kidneys preserved by the present invention, including: a peristaltic pump (1), a filter (2), a main line pressure sensor (3), a sampling valve (4), a T Type pipeline bifurcation buffer box (5), main pipeline air bubble sensor (6), kidney A branch air bubble sensor (7), kidney B branch air bubble sensor (8), exhaust branch solenoid valve (9), kidney A branch solenoid valve (10), kidney B branch solenoid valve (11), kidney A branch flow sensor (13), kidney B branch flow sensor (12), kidney A branch pressure sensor (15), kidney B branch pressure sensor (14), temperature control tank (16), perfusate storage box (18), kidney A storage tank (17), kidney B storage tank (21), kidney A (20), kidney B (22 ), a kidney A interface (19), a kidney B interface (24), a control unit (23), and a display unit (25).

[0041]1) The mechanical perfusion system for the preservation of the isolated kidneys...

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Abstract

The present invention relates to a mechanical perfusion system for preservation of both isolated kidneys. The system comprises: (1) a perfusion liquid temperature control groove for holding a perfusion liquid; (2) two sets of isolated kidney preservation grooves for holding isolated kidneys; (3) pipelines connected between the perfusion liquid temperature control groove and the isolated kidney preservation grooves and used for conveying the perfusion liquid to the isolated kidneys; (4) a pressure detection module for detecting the pressures of the pipelines; (5) a flow rate detection module for detecting the flow rates of the pipelines; (6) a gas bubble detection module for detecting the gas bubbles of the pipelines; (7) an electromagnetic valve module for controlling the on-off of a liquid path; (8) a sampling module for extracting the perfusion liquid; (9) a control module for controlling a peristaltic pump and the electromagnetic valve module; and (10) a display module for displaying the pressures and the flow rates of the pipelines, and the resistance coefficient of the kidney organ.

Description

technical field [0001] The invention belongs to the technical field of kidney transplantation, and in particular relates to a mechanical perfusion system for preservation of isolated kidneys. Background technique [0002] Kidney transplantation technology is the most effective therapy for end-stage renal disease. With the advancement of immune tolerance technology, the application of regulatory T cells (Treg) in the field of kidney transplantation, and the effective control of cell-mediated rejection, kidney transplantation Recipient survival rate continues to improve. With the official launch of organ donation after the death of citizens in my country, there is still a shortage of kidney organ sources. severe. However, the risk of PNF and delayed recovery of graft function (DGF) in marginal donor organ transplantation is higher. [0003] At present, the static cold preservation method is used for clinical donor kidneys. This method has the advantages of simple operation, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
Inventor 邵光业黄光涛杨子江李建辉辛立民
Owner 杭州莱普晟医疗科技有限公司
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