Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

A kind of preparation method of rhubarb total anthraquinone quick-release dropping pills

A technology of rhubarb total anthraquinone and anthraquinone speed, which is applied in the field of preparation of rhubarb total anthraquinone quick-release drop pills, can solve the problems of rhubarb decoction pieces such as poor water solubility, low bioavailability, and accelerated drug dissolution, so as to improve dissolution difficulty, High curative effect and accelerated dissolution time

Active Publication Date: 2020-11-20
ZHEJIANG CHINESE MEDICAL UNIVERSITY
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above-mentioned technical problems, the present invention provides a preparation method of rhubarb total anthraquinone quick-release drop pills. The present invention overcomes the defects of rhubarb decoction pieces such as poor water solubility, low bioavailability, inconvenient taking, and slow onset of action. Rhubarb total anthraquinone immediate-release drop pills can speed up the dissolution of drugs, realize rapid release and increase absorption, so as to better exert the drug effect, especially suitable for the treatment of cardiovascular and cerebrovascular emergencies, and can achieve the purpose of quick-acting and high-efficiency

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of rhubarb total anthraquinone quick-release dropping pills
  • A kind of preparation method of rhubarb total anthraquinone quick-release dropping pills
  • A kind of preparation method of rhubarb total anthraquinone quick-release dropping pills

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0054] A preparation method of rhubarb total anthraquinone quick-release dropping pills, comprising the following steps:

[0055] 1) Weighing the matrix, heating, melting, and mixing;

[0056] 2) adding the total anthraquinone extract of rhubarb into the melted matrix, stirring evenly to obtain a medicinal solution;

[0057] 3) Drop the medicinal liquid into the condensate to form a drop pill;

[0058] 4) Pour off the condensed liquid, absorb the condensed liquid on the dropping pills, and dry it.

[0059] In step 1), the base is one or more of polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer.

[0060] In step 1), the mass ratio of polyethylene glycol 4000 to polyethylene glycol 6000 is 1:0-3, 0:1, 2:1, 3:1, 2:3 or 3:2, polyethylene glycol The mass ratio of the sum of 4000 and polyethylene glycol 6000 to the poloxamer is 1:1:1.

[0061] In step 1), the melting temperature is 65-95°C.

[0062] In step 2), the mass ratio of the rhubarb total anthraquinone ex...

Embodiment 1

[0072] A rhubarb total anthraquinone quick-release drop pill, prepared by the following steps:

[0073] (1) Preparation of rhubarb total anthraquinone extract: powder the rhubarb decoction pieces, pass through a 60-mesh sieve, pretreat the rhubarb decoction pieces powder with sodium lauryl sulfate (0.3wt% of the rhubarb decoction pieces powder mass), use 6 times the 1. Ethanol with a concentration of 30wt% was refluxed for extraction, once for 0.5h each time, the extracts were combined and concentrated until no alcohol smell. The pH of the extract was adjusted to 8.5 with 1.5mol / L NaOH solution, centrifuged (3°C, 3000r / min, 15min), and the supernatant was taken to make a sample solution with a crude drug concentration of 0.15g / mL. Pretreatment of D101 macroporous resin: put the macroporous resin column into 95wt% ethanol which is 3 times higher than its volume, stir and soak for 3 hours, rinse the resin with pure water until it has no alcohol smell, and store it in pure water ...

Embodiment 2

[0078] A rhubarb total anthraquinone quick-release drop pill, prepared by the following steps:

[0079] (1) Preparation of rhubarb total anthraquinone extract: powder the rhubarb decoction pieces, pass through a 60-mesh sieve, pre-treat the rhubarb decoction pieces powder with 8 times the mass 1. The concentration is 50wt% ethanol to carry out reflux extraction, extraction is 2 times, each time is 1h, the extraction solution is combined, concentrated until no alcohol smell. The pH of the extract was adjusted to 9 with 2mol / L NaOH solution, centrifuged (3°C, 3000r / min, 15min), and the supernatant was taken to make a sample solution with a crude drug concentration of 0.2g / mL. Pretreatment of the AB-8 macroporous resin: put the macroporous resin column into 90wt% ethanol which is higher than 2 times its volume, stir and soak for 2 hours, then rinse the resin with pure water until it has no alcohol smell. Save it for later use. The column was wet-packed with a diameter-to-height...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of traditional-Chinese-medicine preparations and discloses a preparation method of quick-release dropping pills with total anthraquinone. The preparation method comprises the following steps of: 1) weighing a matrix, heating for fusion and uniformly mixing; 2) adding total anthraquinone extract into fused matrix, and uniformly stirring to obtain a liquid medicine; 3) dripping the liquid medicine into condensate to form dropping pills; 4) pouring off the condensate, absorbing the condensate on the pills, and drying to obtain the quick-release dropping pills. The prepared quick-release dropping pills with the total anthraquinone has the advantages of good appearance quality, rapid and complete medicine release, high bioavailability, fast and efficient effects, stable quality and the like. The preparation method has very good application prospect and provides a new preparation for clinically preventing and controlling the cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a preparation method of rhubarb total anthraquinone quick-release dropping pills. Background technique [0002] Rhubarb is the dry root and rhizome of Rheum palmatum L, Rheum tauguticumMaxim.ex Balf or medicinal Rheum offciuale Baill of the Polygonaceae plant. It was first recorded in "Shen Nong's Herbal Classic". , is a good medicine suitable for both internal and external use. It has the functions of purging and attacking accumulation, clearing heat and purging fire, detoxifying, anti-inflammatory, anti-oxidation, promoting blood circulation and removing blood stasis. The chemical composition of rhubarb is complex, and the main active ingredients are anthraquinones. In recent years, with the continuous expansion of research on rhubarb by medical workers, its pharmacological effects have been continuously recognized, and new effects have also increased. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/708A61K47/20A61K47/02A61P9/10A61K125/00
CPCA61K9/2009A61K9/2013A61K36/708A61K2236/33A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 石森林万浩芳吴素香丁美红胡锦祥邵敬宝
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com