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Antioxidant and whitening composition for skins and preparation method thereof

An anti-oxidation and composition technology is applied in the field of skin anti-oxidation and whitening compositions and the preparation thereof, which can solve the problems of low sunscreen effect and complicated use process of sunscreen skin care products, and achieves improved sunscreen performance, improved effect, and efficient dissolution and dispersion. performance effect

Active Publication Date: 2019-05-07
派能生物科技(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a skin anti-oxidative whitening composition and its preparation method. By adding a sunscreen whitening agent to skin care products, one molecule of the sunscreen whitening agent contains a p-methoxycinnamate group, thereby effectively Improve its sunscreen performance, and at the same time, the sunscreen and whitening molecules contain a large number of phenolic hydroxyl groups, which can not only effectively inhibit the activity of tyrosinase, and then achieve the whitening effect, but also contain carboxyl groups in the antibacterial moisturizing agent, which can complex with c

Method used

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  • Antioxidant and whitening composition for skins and preparation method thereof
  • Antioxidant and whitening composition for skins and preparation method thereof
  • Antioxidant and whitening composition for skins and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The concrete preparation process of sunscreen whitening agent is as follows:

[0023] Step 1: Add 100g of p-methoxycinnamic acid into 700mL of thionyl chloride, raise the temperature to 60-70°C and stir for 5-6h, then distill to remove unreacted thionyl chloride to obtain p-methoxy Cinnamoyl chloride;

[0024] Step 2: Add 214g of p-methoxycinnamoyl chloride prepared in step 1 to 1200mL of pyridine, and at the same time add 83.6g of glycolic acid to it and raise the temperature to 70-80°C for reflux reaction for 8-9h, then cool to room temperature and crystals precipitate out. The precipitated crystals are washed and dried to obtain product A;

[0025] Step 3: two constant-pressure dropping funnels are installed in the four-necked flask, and the product A prepared in 455.5g step 2 and 168.7g p-hydroxyphenylacetic acid are added respectively in the ethanol solution to be configured as a 50% solution, and then Add the configured product A solution and p-hydroxyphenylacet...

Embodiment 2

[0028]The concrete preparation process of sunscreen whitening agent is as follows:

[0029] Step 1: Add 100g of p-methoxycinnamic acid into 700mL of thionyl chloride, raise the temperature to 60-70°C and stir for 5-6h, then distill to remove unreacted thionyl chloride to obtain p-methoxy Cinnamoyl chloride;

[0030] Step 2: Add 214g of p-methoxycinnamoyl chloride prepared in step 1 to 1200mL of pyridine, and at the same time add 83.6g of glycolic acid to it and raise the temperature to 70-80°C for reflux reaction for 8-9h, then cool to room temperature and crystals precipitate out. The precipitated crystals are washed and dried to obtain product A;

[0031] Step 3: two constant-pressure dropping funnels are installed in the four-necked flask, and the product A prepared in 236g step 2 and 337g p-hydroxyphenylacetic acid are added respectively in the ethanol solution to be configured into a 50% solution, and then the configured The product A solution and p-hydroxyphenylacetic ...

Embodiment 3

[0033] A preparation method of a skin antioxidant whitening composition, the specific preparation process is as follows: 11g of stearic acid, 2.4g of lauryl alcohol, 1.5g of triethanolamine, 4.3g of the sunscreen whitening agent prepared in Example 1 and 6.2g of Example 1 were prepared Add the bacteriostatic antioxidant of the above-mentioned 63g water, and then heat it to 50-55° C. and stir and mix quickly, then stir the mixed solution in a beater for 20-30 minutes and then gradually cool it down to obtain an anti-oxidation whitening composition.

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Abstract

The invention discloses an antioxidant and whitening composition for skins. The composition includes, by weight, 11-13 parts of stearic acid, 2.4-2.8 parts of laurinol, 1.5-1.9 parts of triethanolamine, 4.3-4.7 parts of a sunscreen whitening agent, 6.2-6.5 parts of an antibacterial antioxidant, and 63-67 parts of water. Through the addition of the sunscreen whitening agent in skin care products, and as one molecule in the sunscreen whitening agent contains a p-methoxycinnamate group, sunscreen performance can be effectively enhanced; sunscreen whitening molecules contain large amount of phenolic hydroxyl groups, so that the activity of tyrosinase can be effectively inhibited, whitening effects can be realized; as a bacteriostatic moisturizer contains carboxyl groups which can be in complexing with copper ions, the activity of the tyrosinase can be further inhibited; and the inhibition efficiency on the tyrosinase can be enhanced through synergism, so that efficient whitening and sunscreen performance can be realized.

Description

technical field [0001] The invention belongs to the field of preparation of skin care products, and relates to a skin anti-oxidation and whitening composition and a preparation method thereof. Background technique [0002] Skin care products can effectively improve skin quality and delay aging. In the preparation process of existing skin care products, whitening and anti-aging properties are usually considered. Because skin care products are rich in nutrients, bacteria are easy to breed, which in turn has a certain impact on the skin. , but in the existing technology, polyphenols are usually used to achieve whitening and anti-sun aging. At the same time, polyphenols also have antibacterial properties, which can effectively achieve antibacterial effects, but the antibacterial effect is not obvious. At the same time, sulfadiazine is very effective. The antibacterial agent in skin care products contains a lot of water, but because it is difficult to dissolve in water, it is dif...

Claims

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Application Information

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IPC IPC(8): A61K8/37A61K8/58A61K8/49A61Q17/00A61Q19/00A61Q19/02
Inventor 盘锐伦刘欣
Owner 派能生物科技(深圳)有限公司