Phellinus igniarius fruit body extract product, and applications thereof in preparation of drugs for treating chronic renal failure

A technology of chronic renal failure and Phellinus linteus, applied in the field of medicine, can solve the problems of large toxic and side effects, aggravation of the disease and high recurrence rate, and achieve the effects of simple preparation process, good therapeutic effect and small toxic and side effects

Inactive Publication Date: 2019-05-07
MICROBIOLOGY INST OF SHAANXI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These therapies can improve clinical symptoms, relieve patients' pain, and improve their quality of life, but there are still many insurmountable problems: for example, medical therapy is still difficult to completely block the pathological progress, and the side effects are large; dialysis can only solve part of the kidney. Metabolic problems, the endocrine function of the kidneys cannot be improved; the kidney source for kidney transplantation is limited, and the phenomenon of immune rejection is still difficult to solve for a while
Although western medicine has a certain curative effect, it has the disadvantages of high toxicity and high recurrence rate. For example, Essite is effective in the early stage, but it will aggravate the condition in the later stage, and the blood creatinine and blood urea nitrogen remain high. eventually develop into uremia

Method used

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  • Phellinus igniarius fruit body extract product, and applications thereof in preparation of drugs for treating chronic renal failure
  • Phellinus igniarius fruit body extract product, and applications thereof in preparation of drugs for treating chronic renal failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 10 g of Phellinus fruiting bodies were soaked in 80 times the volume of 80% ethanol aqueous solution for 36 hours, and ultrasonically extracted twice at a frequency of 65KHz for 30 minutes each time. The vacuum degree is 0.1MP, and the time is 50 minutes to concentrate to obtain a brown paste. The vacuum concentration process recovers ethanol. Dissolve the paste in distilled water at a mass ratio of paste:distilled water 1:1.5, add 10 mL of chloroform and reflux in a water bath at 75°C for 3 hours for hydrolysis. After cooling, the chlorine extract was taken, and the aqueous layer was extracted twice with 10 mL of chloroform, and the chloroform extracts were combined and evaporated to dryness to obtain the Phellinus radix fruiting body extract.

Embodiment 2

[0031] 10 g of Phellinus fruiting bodies were soaked in 70 times the volume of 85% ethanol aqueous solution for 35 hours, and ultrasonically extracted twice at a frequency of 65KHz for 30 minutes each time. The vacuum degree is 0.1MP, and the time is 60 minutes to concentrate to obtain a brown paste. The vacuum concentration process recovers ethanol. Dissolve the paste in distilled water at a mass ratio of paste:distilled water 1:1.5, add 10 mL of chloroform and reflux in a water bath at 80°C for 3 hours for hydrolysis. After cooling, the chlorine extract was taken, and the aqueous layer was extracted twice with 10 mL of chloroform, and the chloroform extracts were combined and evaporated to dryness to obtain the Phellinus radix fruiting body extract.

Embodiment 3

[0033]The Phellinus fruiting body extract obtained in Example 1 is formulated with tap water (g / mL) containing 2% gum arabic powder to be an oral liquid preparation; g / mL.

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Abstract

The invention provides a phellinus igniarius fruit body extract product, and applications thereof in the preparation of drugs for treating chronic renal failure, and belongs to the technical field ofmedicines. A method for preparing the extract product includes the following steps: 1) performing ultrasonic extraction after mixing and soaking phellinus igniarius fruit bodies and an ethanol aqueoussolution so that an extract solution can be obtained; 2) concentrating the extract solution to obtain extract; and 3) performing water dissolution on the extract to mix with chloroform, and performing extraction and concentration so that the phellinus igniarius fruit body extract product can be obtained. The extract product can be used for preparing drugs which can treat chronic renal failure, and is good in treating effect; the extract product can reduce urea nitrogen and serum creatinine, and the reduction of the urea nitrogen and serum creatinine has significantly difference at statistics;and the extract product is small in toxic and side effect and low in cost.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an extract of Phellinus radix fruiting body and its application in preparing medicine for treating chronic renal failure. Background technique [0002] Chronic renal failure (CRF) refers to the slowly progressive renal function damage caused by various kidney diseases. Due to the irreversible loss of nephrons and renal function, it leads to the retention of metabolites and toxins, water, electrolytes and acid Alkaline balance disorder and endocrine disorder finally lead to uremia and complete loss of renal function, causing a series of clinical symptoms and clinical syndrome composed of biochemical, endocrine and other metabolic disorders. From the onset of the primary disease to the beginning of renal insufficiency, the interval can be several years to more than ten years. Chronic renal failure is a severe stage of renal insufficiency. In the treatment of chronic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61P13/12
Inventor 雷萍吴亚召张文隽渠敬峰钱磊
Owner MICROBIOLOGY INST OF SHAANXI
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