Application of reduced nicotinamide adenine dinucleotide phosphate to preparation of antiviral drugs
A reduced type and drug technology, applied in the field of medicine, can solve the problems that the application of reduced nicotinamide adenine dinucleotide phosphate has not been reported, and achieve the effect of treating infection
Active Publication Date: 2019-06-07
SICHUAN UNIV
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- Abstract
- Description
- Claims
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Problems solved by technology
So far, the application of reduced nicotinamide adenine dinucleotide phosphate in antiviral infection has not been reported
Method used
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Embodiment 1
[0039] Embodiment 1 The preparation of antiviral drug of the present invention
[0040] The reduced nicotinamide adenine dinucleotide phosphate (NADPH) is added with pharmaceutically acceptable auxiliary materials to prepare the medicine.
[0041] The beneficial effect of the present invention is verified by the mode of test example below:
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The invention discloses an application of a compound, an optical isomer thereof, pharmaceutically acceptable salt, hydrate or solvate as shown in a formula I, to preparation of anti RNA virus medicines. Reduced nicotinamide adenine dinucleotide phosphate can effectively restrain RNA polymerase, can effectively restrain RNA viruses, can be particularly used for restraining enterovirus D68, can be used for preparing the anti RNA virus medicines, can be used for preventing and / or treating infection of the RNA viruses, and is favorable in clinical application prospects.(As shown in the description)
Description
technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to the use of reduced nicotinamide adenine dinucleotide phosphate (NADPH) in the preparation of antiviral drugs. Background technique [0002] Enterovirus D68 (Enterovirus D68, Picornaviridae, Enterovirus) is a single-stranded positive-sense RNA virus without an envelope. This virus is one of the common human pathogens. It can cause fever or death in severe cases A series of clinical symptoms such as meningitis. There are four groups of enteroviruses that are now recognized: A, B, C, and D. EV-D68 is a member of the five serotypes (D70, D111, D68, D94, D120) of the EV-D group virus, and some biological characteristics and epidemic rules of this virus are different from the typical EV in the past. It can be transmitted through the respiratory tract, and severely infected patients can show neurological symptoms similar to those caused by poliovirus, with some mortality...
Claims
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Inventor 苏丹王美林卢涛罗桂林李黎
Owner SICHUAN UNIV
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