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Preparation method of porous solid composite silk material

A composite wire, solid technology, applied in the direction of prosthesis, medical science, etc., can solve the problem of limiting wide application, and achieve the effect of simple process operation, firm combination and wide application

Active Publication Date: 2019-06-11
江西丝科生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the bulk form of silk fibroin is mainly a porous scaffold, and there is no porous-solid composite silk fibroin material, which limits its wide application in the fields of biomedicine and new microelectronics.

Method used

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  • Preparation method of porous solid composite silk material
  • Preparation method of porous solid composite silk material
  • Preparation method of porous solid composite silk material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1 of the present invention provides a kind of porous-solid composite silk material preparation method, such as figure 1 As shown, the preparation method of the porous-solid composite silk material includes the following steps.

[0052] S1, the silk fibroin is dissolved in hexafluoroisopropanol to obtain the following figure 2 The silk fibroin solution 1 shown ( figure 2 1 in represents silk fibroin solution).

[0053] Specifically, each 10g cocoon was cut into pieces and placed in 4L of 2g / L sodium carbonate solution, heated to boil in an electric furnace and magnetically stirred at a speed of 200r / min, and the heating time was 60 minutes. Then, each portion of boiled silk is placed in 2L of ultrapure water, stirred, washed and kneaded dry, repeated 6 times, and then dried, the stirring speed is 200r / min, and the stirring time is 20min. The volume of ultrapure water changed each time is 2L, the drying method is 25°C and normal pressure (0.1MPa). Next, i...

Embodiment 2

[0071] In Example 2, the lithium bromide solution in S1 was replaced with a lithium thiocyanate solution, and other operations were the same as in Example 1.

[0072] The preparation method of the porous-solid composite silk material provided by the embodiment of the present invention provided in this example has simple process operation and is suitable for industrialization; the porous-solid composite silk material prepared by it has adjustable porosity and void diameter, porous structure and solid structure A porous-solid composite silk material that combines firmness, biodegradability, and adjustable mechanical properties.

Embodiment 3

[0074] In Example 3, the mass ratio of powdered silk fibroin to hexafluoroisopropanol is 1:1, and other operations are the same as in Example 1.

[0075] The preparation method of the porous-solid composite silk material provided by the embodiment of the present invention provided in this example has simple process operation and is suitable for industrialization; the porous-solid composite silk material prepared by it has adjustable porosity and void diameter, porous structure and solid structure A porous-solid composite silk material that combines firmness, biodegradability, and adjustable mechanical properties.

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Abstract

The invention provides a preparation method of a porous solid composite silk material. The preparation method comprises the steps: (1) dissolving silk fibroin in hexafluoroisopropanol so as to obtaina silk fibroin solution; (2) injecting the silk fibroin solution into a porous mold, and performing still standing, wherein the porous mold comprises a peripheral wall and a protective shell, and a plurality of openings are formed in the peripheral wall; (3) filling the silk fibroin solution in the porous mold with water-soluble salt particles so as to obtain a water-soluble salt particle-silk fibroin solution mixture; (4) removing the protective shell of the porous mold, immersing the obtained porous mold containing the water-soluble salt particle-silk fibroin solution mixture in methanol soas to obtain water-soluble salt particle-containing silk fibroin solid; and (5) removing methanol and the water-soluble salt particles in the water-soluble salt particle-containing silk fibroin solidso as to obtain the porous solid composite silk fibroin material.

Description

technical field [0001] The invention relates to the technical field of organic polymer materials, and particularly designs a porous-solid composite silk material and a preparation method thereof. Background technique [0002] Bio-based materials with excellent performance, environmental friendliness, variety, high added value and wide application have always been one of the important areas for the development of my country's strategic emerging industries and biomass industry. Biomacromolecular materials, especially biomacromolecular materials of natural products, have many unique advantages in the field of polymer materials, such as good biocompatibility, degradable characteristics and wide range of sources. [0003] As a biological material with a long history of application, silk protein material is one of the earliest natural protein materials developed by human beings. Among them, silk fibroin is the main constituent material of silk (accounting for about 70% of the mas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J9/26A61L27/22A61L27/56A61L27/58C08L89/00
Inventor 陶虎柳克银
Owner 江西丝科生物科技有限公司
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