Noninvasive intratracheal drug administration device applied to laboratory mice and drug administration method

Abstract

The invention discloses a noninvasive intratracheal drug administration device applied to laboratory mice. The noninvasive intratracheal drug administration device comprises a supporting object, a flat plate, a mouse fixator and a needle-threading device, the supporting object is used for fixing the flat plate, and a 45-degree angle is formed between the fixing flat plate and the horizontal planethrough the supporting object; the mouse fixator is arranged on the flat plate and located in the lower middle part of the flat plate, and a screw fixed into the flat plate is arranged on the upper middle part of the flat plate; and the needle-threading device is composed of a plastic handle and a coil, the screw penetrates through the coil to enable the needle-threading device to be hung on the flat plate, and the plastic handle of the needle-threading device is firmly fixed to the flat plate through a rubber band. When the drug administration device is adopted to administrate drugs to the laboratory mice, the step that the epidermis and fascias are cut up to expose tracheas, and then drug administration is conducted is not needed, the noninvasive intratracheal drug administration deviceis noninvasive to the laboratory mice, an operation method is simple, the cost is low, the influence on a human body is avoided, and the whole process can be completed in a spf-level animal room.

Description

technical field [0001] The invention belongs to the technical field of medical drug administration, and in particular relates to a non-invasive intratracheal drug delivery device and drug delivery method applied to experimental mice. Background technique [0002] There are two main types of traditional intratracheal drug administration in mice. One is to incise the epidermis and fascia layer by layer to expose the trachea, and then perform tracheotomy or directly insert the needle into the exposed trachea for drug administration; The mice brought unnecessary trauma, increased the infection rate and mortality rate, and at the same time needed to cooperate with the tedious nursing work in the later stage, which increased the cost of manpower and materials, and was not conducive to the implementation of a small amount of multiple drug administration experiments; another The first method is to use an atomization device to administer drugs, which will increase the loss of drugs w...

AI Technical Summary

Problems solved by technology

[0002] There are two main types of traditional intratracheal drug administration in mice. One is to incise the epidermis and fascia layer by layer to expose the trachea, and then perform tracheotomy or directly insert the needle into the exposed trachea for drug administration; The mice brought unnecessary trauma, increased the infection rate and mortality rate, and at the same time needed to cooperate with the tedious nursing work in the later stage, which increased the cost of manpower and materials, and was not conducive to the implementation of a small amount of multiple drug administration experiments; another The first method is to use an atomization device to administer drugs, which will increase the loss of drugs while atomizing. If toxic and harmful experimental drugs are used, it is easy to cause damage to the airways of surrounding people; The level animal room has no available power wiring. When using the atomization device, the mice need to be taken to a place with power supply. It is impossible to administer drugs to the mice in the spf level sterile animal room, which also increases the risk of infection. chance, increased mortality in mice

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