A kind of antibacterial drug-loaded beaded nanofiber membrane and preparation method thereof

A technology of nanofiber membranes and antibacterial drugs, applied in antibacterial drugs, fiber treatment, pharmaceutical formulations, etc., can solve problems such as easy to produce violent release, and achieve the effect of convenient preparation method, low cost, and good degradability

Active Publication Date: 2022-07-08
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drugs or biomolecules loaded on electrospun fibers are extremely prone to burst release phenomenon in the initial stage, which is very unfavorable.

Method used

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  • A kind of antibacterial drug-loaded beaded nanofiber membrane and preparation method thereof
  • A kind of antibacterial drug-loaded beaded nanofiber membrane and preparation method thereof
  • A kind of antibacterial drug-loaded beaded nanofiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Accurately weigh a total of 1000 mg of polylactic acid (PLA) and polycaprolactone (PCL) with a balance (the molecular weight of PLA is 100,000, the molecular weight of PCL is 60,000, and the mass ratio of PLA / PCL is 1:1), and the curcumin ( CUR) 80 mg was dissolved in dichloromethane and methanol (the volume ratio of the solution was 7:5), so that the mass fraction of the carrier material was 8%, and the bottle mouth was sealed with a sealing film to prevent the solvent from volatilizing. Stir on a vortexer until it is completely dissolved to obtain a spinning dope. The electrospinning solution was electrospun with an electrospinning apparatus under the conditions of 25° C. and a relative humidity of 35-60%, using a latex glove as a receiving plate. The applied voltage was 12KV, the receiving distance was 8cm, the electrospinning solution was 3mL, the spinning advancement speed was 0.5mL / min, and the diameter of the spinneret was 0.51mm. The organic solvent was volatil...

Embodiment 2

[0035] Accurately weigh a total of 1000 mg of polylactic acid (PLA) and polycaprolactone (PCL) with a balance (the molecular weight of PLA is 100,000, the molecular weight of PCL is 60,000, and the mass ratio of PLA / PCL is 1:1). Tea gallate (EGCG) 80mg was dissolved in dichloromethane and methanol (the volume ratio of the solution was 7:5), the mass fraction of the carrier material was 6%, and the bottle mouth was sealed with a sealing film to prevent the solvent from volatilizing . Stir on a vortexer until it is completely dissolved to obtain a spinning dope. The electrospinning solution was electrospun with an electrospinning apparatus under the conditions of 25° C. and a relative humidity of 35-60%, using a latex glove as a receiving plate. The applied voltage was 12KV, the receiving distance was 8cm, the electrospinning solution was 3mL, the spinning advancement speed was 0.5mL / min, and the diameter of the spinneret was 0.51mm. After volatilizing the organic solvent and ...

Embodiment 3

[0037] Accurately weigh a total of 1000 mg of polylactic acid (PLA) and polycaprolactone (PCL) with a balance (the molecular weight of PLA is 100,000, the molecular weight of PCL is 60,000, and the mass ratio of PLA / PCL is 1:1). Tea gallate (EGCG) 20mg and curcumin (CUR) 80mg were dissolved in dichloromethane and methanol (the volume ratio of the solution was 7:5) to make the mass fraction of the carrier material 10%, and sealed with parafilm A good bottle mouth to prevent solvent evaporation. Stir on a vortexer until it is completely dissolved to obtain a spinning dope. The electrospinning solution was electrospun with an electrospinning apparatus under the conditions of 25° C. and a relative humidity of 35-60%, using a latex glove as a receiving plate. The applied voltage was 12KV, the receiving distance was 8cm, the electrospinning solution was 3mL, the spinning advancement speed was 0.5mL / min, and the diameter of the spinneret was 0.51mm. The organic solvent was volatili...

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Abstract

The invention discloses a beaded nanofiber membrane loaded with antibacterial drugs and a preparation method thereof. The antibacterial drug-loaded beaded nanofiber membrane includes an antibacterial drug and a beaded fiber membrane carrier, wherein the antibacterial drug is at least one of epigallocatechin gallate and curcumin. At the same time, a preparation method of the antibacterial drug-loaded beaded nanofiber membrane is also disclosed. The beaded nanofibers loaded with epigallocatechin gallate and / or curcumin obtained by the present invention have good biocompatibility and degradability, and the beads connected with the fibrils can serve as a storage reservoir for drugs, which can make The internal drug is continuously and slowly released, so as to maintain a stable and effective concentration and achieve the purpose of effective antibacterial. The preparation method of the invention is convenient and low in cost, and the antibacterial effect of the prepared beaded nanofiber membrane on Candida albicans, Escherichia coli and Staphylococcus aureus reaches more than 95%.

Description

technical field [0001] The invention belongs to the technical field of drug carriers, in particular to a beaded nanofiber membrane loaded with antibacterial drugs and a preparation method thereof. Background technique [0002] Antibacterial fibers generally refer to fibers mixed with antibacterial agents or treated with antibacterial surfaces, which have antibacterial and bactericidal functions against methicillin-resistant Staphylococcus aureus, which can prevent infection and infection. [0003] Epigallocatechin gallate (EGCG) is a flavanol compound with off-white or white powder, and is an important constituent of green tea polyphenols. EGCG not only has anti-oxidation, anti-tumor, anti-virus, anti-angiogenesis, anti-thrombotic effects, but also has strong antibacterial activity, and has a certain killing effect on most microorganisms including Escherichia coli in nature. . [0004] Curcumin (CUR) is a yellow powdery, bitter-tasting hydrophobic polyphenol that is widely...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/70A61K47/34A61K31/353A61K31/12A61P31/04A61P31/10D01D5/00D04H1/728
CPCY02A50/30
Inventor马盼盼刘群峰于珊顾珩黄德群张锦
OwnerGUANGDONG PROV MEDICAL INSTR INST