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Method for researching teenager myoclonic epilepsy based on dMRI

A technique for myoclonus, adolescents, applied in the field of medical imaging, which can solve problems such as inaccurate results

Pending Publication Date: 2019-06-21
TIANJIN UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

However, when DTI is used for whole-brain fiber reconstruction, due to the limitations of its imaging characteristics, it can only show the direction of one fiber and cannot solve the problem of crossing of fiber bundles in the brain, and the result is not accurate enough.

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  • Method for researching teenager myoclonic epilepsy based on dMRI
  • Method for researching teenager myoclonic epilepsy based on dMRI
  • Method for researching teenager myoclonic epilepsy based on dMRI

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Embodiment Construction

[0021] The present invention uses two dMRI techniques: QBI and NODDI. Using QBI to reconstruct the orientation distribution function (orientationdistribution function, ODF) to display the direction of nerve fibers, to obtain the three-dimensional nerve fiber bundles of the whole brain. A quantitative parameter describing the microstructural information of brain tissue was used: the parameter intracellular volume fraction (ICVF) from NODDI. Then combined with the complex network analysis method based on graph theory technology, 90 brain regions based on the unified brain partition template were used as network nodes, and the weighted ICVF values ​​of fiber tracts connecting brain regions were used as network edges to construct 33 JME patients and gender and age matching Structural brain networks of 10 normal individuals: ICVF weighted networks. Statistical analysis was performed on the brain structure network characteristics of the two groups of people, including three global ...

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Abstract

The invention relates to a method for researching teenager myoclonic epilepsy based on dMRI. The method comprises the following steps of constructing a QBI model, and obtaining an orientation distribution function (ODF) for describing water molecule space diffusion direction; constructing a NODDI model, and a parameter ICVF which describes cerebral white matter structure information; constructinga three-dimensional nerve fiber bundle of the whole brain based on the orientation distribution function (ODF) of the QBI model; constructing ICVF-based brain structure networks of a JME patient and anormal person based on the constructed brain three-dimensional nerve fiber bundle, 90 brain areas and the ICVF data; extracting the network characteristic of the brain ICVF structure network, and performing statistics and comparison on the index difference between the JME patient and the normal person.

Description

technical field [0001] The invention relates to the fields of medical images, computer imaging and mathematics, and realizes the research on the pathogenesis of JME through image preprocessing and model construction, as well as a complex network mathematical analysis method based on graph theory. Background technique [0002] JME is a treatment-resistant epilepsy characterized clinically by generalized tonic-clonic seizures. Affected patients usually have onset during adolescence and symptoms are usually characterized by irregular, arhythmic myoclonic seizures, often in the upper extremities, often within a short time of morning. Antiepileptic drugs are effective in JME patients, but they are prone to relapse after drug withdrawal, and most patients need life-long medication. The pathogenesis of JME has not been fully clarified, but a large number of studies have proved that JME is related to brain structural abnormalities, especially gray matter and white matter abnormalit...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/70G16H50/20
Inventor 姚麟倩李锵关欣
Owner TIANJIN UNIV