1-o-acetyl inulalide spiroaryl isoxazoline derivatives and their medicinal uses

Abstract

The invention provides a 1-O-acetyl inulalide spiroaryl isoxazoline derivative and its medical use, belonging to the technical field of medicine. It specifically relates to the compound represented by formula I and the pharmacological effect of inhibiting the production of leukotrienes. The results of pharmacological experiments showed that 1‑O‑acetyl inulalide spiroarylisoxazoline derivatives can inhibit mast cell leukotriene C 4 Generation, and then exert anti-inflammatory and anti-asthma pharmacological effects through this mechanism of action.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and specifically relates to 1-O-acetyl inulalide spiroaryl isoxazoline derivatives and their medical application. Background technique

[0002] Inula japonica Thunb (Inula japonica Thunb / Inula britannica L.) is a traditional Chinese herbal medicine of the genus Inula japonica Thunb in the family Compositae. , slightly warm; returns to the lung, spleen, stomach, and large intestine meridians; has the effects of lowering qi, eliminating phlegm, promoting water flow, and stopping vomiting; mainly treats wind-cold cough, accumulation of phlegm and retention, tightness in the chest and diaphragm, wheezing and coughing, excessive phlegm, and vomiting , hard heart (National Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China [M]. Part One. Beijing: China Medical Science and Technology Press, 2015: 326). The dried roots and leaves of Inula inula are used as traditional Chinese herb...

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