The present invention relates to one kind of somatostation aqua preparation and its preparation process and application in preparing medicine for preventing and treating serious acute esophagus varicose hemorrhage, acute gastric and duodenal ulcer hemorrhage, acute erosive gastritis, acute hemorrhagic gastritis, etc. The preparation consists of somatostation in 0.1-1000 mg each 0.1-500 ml, medicinal supplementary material, which may be mannitol, polyglycol, cyclodextrin, etc., and water. The preparation process includes compounding, sterilizing, packing, and other steps. The somatostation aqua preparation has high stability, easy preparation and other features, and has wide application foreground in preparing medicine for preventing and treating serious acute esophagus varicose hemorrhage, acute gastric and duodenal ulcer hemorrhage, acute erosive gastritis, acute hemorrhagic gastritis, etc.