Application of a kind of interleukin 2 in the preparation of a medicine for treating pemphigus vulgaris oral erosion

Abstract

The invention belongs to the field of medicine preparation, and particularly discloses application of interleukin 2 in preparing medicine for treating pemphigus vulgaris oral erosion. Accordingly, lowdose of recombinant human interleukin 2 is innovatively and externally applied to the oral mucosa erosive surface caused by the pemphigus vulgaris, the oral mucosa erosion caused by the pemphigus vulgaris can be quickly recovered, and pain can be effectively relieved.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to the application of interleukin 2 in the preparation of medicine for treating pemphigus vulgaris oral erosion. [0002] technical background [0003] Pemphigus vulgaris is a relatively common bullous skin disease in dermatology clinical practice. It is manifested by a large number of blisters and bullae on the skin and mucous membranes of the whole body, which are easy to rupture and hard to heal on the erosive surface. About 60% of patients with pemphigus vulgaris may have blisters and bullae on the oral mucosa, and spontaneously rupture to form a long-lasting erosion surface, because this oral erosion often lasts for several months or even years, accompanied by obvious tenderness , seriously affecting the patient's eating, drinking and daily life, and bringing great pain to the patient's body and mind[1]. In addition, some patients may only present with persistent...

AI Technical Summary

Problems solved by technology

These treatments often have relatively positive effects on the skin lesions of pemphigus vulgaris, but the curative effect on the oral mucosal lesions of most patients is relatively slow; even after regular treatment, the skin lesions have been controlled, and the oral erosion lesions can still persist for several weeks to several months. Healing, pain is obvious, and the patient's quality of life is greatly affected

In view of this situation, basic fibroblast growth factor is recommended to be used externally on the erosive surface in the clinical guidelines, and a gargle containing lidocaine, nystatin, and physiological sodium chloride solution can also be prepared for gargling to promote healing. healing, pain relief, and prevention of local infection [2], however, these topical treatments are not satisfactory in promoting the healing of oral erosions and reducing pain

[0005] In recent years, some biological agents targeting B cells, such as anti-CD20 monoclonal antibodies (including rituximab (Rituximab), veltuzumab (Veltuzumab), etc.), as well as plasma exchange, immunoadsorption, etc. Both treatment methods have shown positive effects on pemphigus vulgaris[2-7], but the high price of the two and the invasiveness of the latter limit the use of a considerable number of patients; moreover, these new treatment methods There is no targeted large-sample clinical data report on the treatment effect of oral mucosal erosion in pemphigus vulgaris[4]; a single case report suggested that pemphigus vulgaris patients who improved after receiving veltuzumab therapy maintained Recurrent episodes of oral mucosal erosions persisted during treatment [8]

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