Radiotherapy dosage verification method and system

A radiotherapy and dosing technique, applied in the medical field, can solve problems such as ignoring the influence of radiation-resistant cell subsets, underestimating normal tissue responses, and not reflecting vascular and interstitial damage, and achieving reliable verification results

Active Publication Date: 2019-07-05
SICHUAN CANCER HOSPITAL
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Problems solved by technology

The traditional "L-Q model" and its derived biological effect dose (BED) model have poor fit in the high-dose region and may overestimate tumor control and underestimate normal tissue response
The L-Q model only fits the data through in vitro experiments, de

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  • Radiotherapy dosage verification method and system
  • Radiotherapy dosage verification method and system

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Embodiment Construction

[0032] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. The components of the embodiments of the invention generally described and illustrated in the figures herein may be arranged and designed in a variety of different configurations. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative efforts belong to the protection scope of the present invention.

[0033] see figure 1 , the present embodiment provid...

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Abstract

The invention relates to a radiotherapy dosage verification method and system. The method includes steps: S1, receiving a CT image obtained before radiotherapy, and sketching a target area in the CT image; S2, extracting a plurality of radiomics characteristics of the target area; S3, screening out the radiomics characteristics in remarkable relevance to TRR (tumor regression ratio) from the multiple extracted radiomics characteristics; S4, presetting a dosage value, recognizing the CT image processed in the step S3 by a pre-trained radiomics model, and outputting to obtain the TRR under the given dosage value. A novel idea is provided, the radiomics model is obtained by training based on a machine learning method, the given dosage value is verified by virtue of the TRR outputted by the radiomics model, a prediction result is insusceptible to single dosage, and high reliability of a verification result is realized.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method and system for verifying radiation therapy dose. Background technique [0002] The current radiotherapy dose is adjusted according to the individual biological effect dose (Bd), the formula is Bd=E / α=nd(1+d / [α / β])-log e 2(T-TK) / αTp, where Bd is BED, which is the biologically effective dose, E is the total cell index killing, α is the irreparable killing coefficient, that is, the exponential killing caused by irradiation per Gy, and β is the repairable killing coefficient, that is, the square of the exponential killing caused by irradiation per Gy, n is the number of fractionated irradiations, d is the dose of a single fractionation, T is the total irradiation time, Tk is the start time of cell repopulation, Tp is the doubling of the number of cells in continuous irradiation Average time. See "The linear quadratic formula and progress in fractionated radiotherapy," by ...

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Application Information

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IPC IPC(8): A61N5/10
CPCA61N5/103A61N2005/0627
Inventor 王卫东闫梦梦
Owner SICHUAN CANCER HOSPITAL
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