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A kind of high-efficiency antibacterial pharmaceutical composition and its preparation method and application

A composition and drug technology, applied in the field of medicine, to achieve the effects of ensuring activity, improving drug efficacy, and optimizing preparation methods

Active Publication Date: 2020-07-03
YUAN INT GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above-mentioned patents, chlorhexidine is used in the preparation of soap to prevent bacterial infection, and it has not been found that chlorhexidine is used in medicine to prepare a kind of skin disease that can treat bacterial infections.

Method used

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  • A kind of high-efficiency antibacterial pharmaceutical composition and its preparation method and application
  • A kind of high-efficiency antibacterial pharmaceutical composition and its preparation method and application
  • A kind of high-efficiency antibacterial pharmaceutical composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 antibacterial pharmaceutical composition and its preparation

[0025] Composition composition: 6 parts of chlorhexidine acetate, 80 parts of sulfur, 6 parts of allantoin, 160 parts of 15# white oil, 60 parts of 340B-emulsifier, 60 parts of A165 emulsifier, 60 parts of 16-18 alcohol, 100 parts of glycerin , 200 parts of propylene glycol, 2 parts of methylparaben, 1 part of propylparaben, 80 parts of isopropyl myristate, 40 parts of stearic acid, 20 parts of silicone oil, 20 parts of azone, 1200 parts of purified water.

[0026] Preparation:

[0027] (1) Prepare the water phase: mix and stir glycerin, allantoin, and purified water, and heat up to 70°C to obtain the water phase;

[0028] (2) Preparation of oil phase: 340B-emulsifier, 16-18 alcohol, methylparaben, propylparaben, A165 emulsifier, stearic acid, 15# white oil, azone, silicone oil, nutmeg Acetate isopropyl ester was mixed and stirred, and the temperature was raised to 70°C to obtain an oil phase;...

Embodiment 2

[0031] Embodiment 2 antibacterial pharmaceutical composition and its preparation

[0032] Composition composition: 4 parts of chlorhexidine acetate, 70 parts of sulfur, 4 parts of allantoin, 150 parts of 15# white oil, 50 parts of 340B-emulsifier, 50 parts of A165 emulsifier, 50 parts of 16-18 alcohol, 80 parts of glycerin , 190 parts of propylene glycol, 1 part of methylparaben, 0.5 part of propylparaben, 70 parts of isopropyl myristate, 30 parts of stearic acid, 10 parts of silicone oil, 10 parts of azone, and 1000 parts of purified water.

[0033] Preparation:

[0034] (1) Prepare the water phase: mix and stir glycerin, allantoin, and purified water, and heat up to 60°C to obtain the water phase;

[0035] (2) Preparation of oil phase: 340B-emulsifier, 16-18 alcohol, methylparaben, propylparaben, A165 emulsifier, stearic acid, 15# white oil, azone, silicone oil, nutmeg Mix and stir isopropyl acetate, and heat up to 60°C to obtain an oil phase;

[0036] (3) After mixing th...

Embodiment 3

[0038] Embodiment 3 antibacterial pharmaceutical composition and its preparation

[0039]Composition composition: 8 parts of chlorhexidine acetate, 100 parts of sulfur, 8 parts of allantoin, 180 parts of 15# white oil, 70 parts of 340B-emulsifier, 70 parts of A165 emulsifier, 70 parts of 16-18 alcohol, 120 parts of glycerin , 220 parts of propylene glycol, 3 parts of methylparaben, 3 parts of propylparaben, 100 parts of isopropyl myristate, 50 parts of stearic acid, 30 parts of silicone oil, 30 parts of azone, 1500 parts of purified water.

[0040] Preparation:

[0041] (1) Prepare the water phase: mix and stir glycerin, allantoin, and purified water, and heat up to 80°C to obtain the water phase;

[0042] (2) Preparation of oil phase: 340B-emulsifier, 16-18 alcohol, methylparaben, propylparaben, A165 emulsifier, stearic acid, 15# white oil, azone, silicone oil, nutmeg Acetate isopropyl ester was mixed and stirred, and the temperature was raised to 80°C to obtain an oil phas...

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PUM

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Abstract

The invention provides an efficient bacteriostatic drug composition. Three components, namely chlorhexidine acetate, sulfur and allantoin, serve as the active ingredients of the composition, pathogenic bacteria parasitic on the skin can be effectively inhibited through the synergistic effects of the three components, and the composition especially has a significant inhibition effect on staphylococcus aureus, escherichia coli and candida albicans. At the same time, by strictly controlling the process temperature in the preparation process, the composition can effectively ensure the drug activity, give play to the synergistic effects of the components, and enhance the bacteriostatic effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a high-efficiency antibacterial composition, a preparation method and application thereof. Background technique [0002] As the largest organ of the human body, the skin plays an important role in sensing external stimuli, regulating body temperature, regulating water evaporation loss, protecting various tissues and organs in the body from physical and chemical damage, and resisting the invasion of pathogenic microorganisms. The skin participates in the metabolic process of the human body, which is of great significance for maintaining the stability of the internal environment of the human body and maintaining the normal physiological functions of the body. The skin area of ​​an adult is about 1.8m 2 , a large number of microorganisms live on the skin, which can be as high as 10 7 piece / cm -2 . These microbial flora are closely related to human skin and human hea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/155A61K33/04A61K31/4166A61P31/04A61P31/10A61P17/00A61P17/10A61P29/00
CPCA61K31/155A61K31/4166A61K33/04A61P17/00A61P17/10A61P29/00A61P31/04A61P31/10A61K2300/00Y02A50/30
Inventor 王若研田德海张军史跃满黄炎冯雪陈晓彤李建石佳袁一鸣何爱琳王翼超刘爽
Owner YUAN INT GROUP
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