Tropane alkaloid extraction technology

Abstract

The invention discloses a tropane alkaloid extraction technology, which comprises the following steps: crushing roots of the Tibetan medicine Anisodus tanguticus (Maxim.) Pascher and then extracting to obtain an extract, filtering the extract through a ceramic membrane to remove impurities such as vegetable protein, colloid, suspensions and the like to obtain a ceramic membrane clear liquid, removing impurities such as small molecular protein, pigments and the like through a ultrafiltration membrane so as to obtain a ultrafiltration membrane clear liquid, adsorbing Anisodus tanguticus (Maxim.)Pascher through macroporous adsorption resin, parsing through ethanol to obtain a macroporous adsorption resin parsing solution, concentrating through a nanofiltration membrane to obtain a nanofiltration membrane concentrated solution containing tropane alkaloid, and evaporating and crystallizing. The technical problem that impurities such as suspensions, colloid, protein, etc. in the extractionprocess of tropane alkaloid are easy to pollute macroporous adsorption resin in the subsequent process is solved. In comparison with the prior art, the equipment process is simple, degree of automation is high, the control process is simple, and production efficiency and product recovery rate are improved.

Description

technical field [0001] The invention belongs to the field of natural medicine extraction, and in particular relates to an extraction process of tropane alkaloids. Background technique [0002] Anisodus tanguticus (Maxim.) Pascher is a perennial herb of the genus Anisodora in the family Solanaceae. Stems glabrous or puberulent; roots thick, nearly fleshy. Leaf blade papery or nearly firm papery, oblong to narrowly oblong-ovate, apex acute or acuminate, base cuneate or decurrent, with gnawing serrations, both sides glabrous; both sides of petiole slightly winged . Flowers drooping or sometimes erect, calyx bell-shaped or funnel-shaped, firm papery, outside puberulent or nearly glabrous; corolla bell-shaped or funnel-shaped, purple or dark purple, hidden or only the eaves exposed Outside the calyx, the inside of the corolla tube is pilose, the lobes are semicircular; the pistil is slightly longer than the stamen; the flower disc is light yellow. Fruit globose or nearly ovoi...

AI Technical Summary

Problems solved by technology

The wild resources of anisopolamine root in Sichuan are extremely rich, mainly distributed in Ganzi Prefecture and Aba Prefecture. At present, except for the use of local Tibetan medicine as medicinal materials, a large number of resources are not fully utilized

[0006] (1) The amount of organic solvent is large, the cost of raw materials is high, and the organic solvent is not safe. All electrical equipment in the extraction workshop must adopt explosion-proof grades, which greatly increases the cost;

[0007] (2), the use of organic solvent extraction process will introduce new impurities, and the product quality is not high;

[0008] (3), there are many steps, the route is long, and the yield of the product is not high;

[0009] (4) Serious pollution and severe environmental problems

[0010] (5), not suitable for large-scale production, high unit output cost

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