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Medicine and polypeptide analogue for preventing/treating synuclein disease

A technology of synuclein and analogues, applied in the medical field, can solve the problems that cannot prevent the development of the disease, cannot cure the disease, etc., and achieve the effect of clearing synuclein and effective drug action

Active Publication Date: 2019-07-16
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above two categories of drugs can improve symptoms, they cannot prevent the development of the disease, nor can they cure the disease.

Method used

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  • Medicine and polypeptide analogue for preventing/treating synuclein disease
  • Medicine and polypeptide analogue for preventing/treating synuclein disease
  • Medicine and polypeptide analogue for preventing/treating synuclein disease

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Embodiment Construction

[0021] The following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all of them. Based on the embodiments in this application, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of this application.

[0022] The present application provides a drug for preventing / treating synucleinopathy (for example, Parkinson's disease, etc.), the drug comprising a polypeptide analog at an effective dose for preventing / treating synucleinopathy; the polypeptide analog includes: the The polypeptide analog Tat-β-wrapins-KFERQ includes: amino acid fragments in the transcriptional transactivator Tat, amino acid fragments in the engineered binding protein β-wrapins, and the key s...

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Abstract

The application discloses a medicine and polypeptide analogue for preventing / treating synuclein disease. The medicine comprises the polypeptide analogue having effective dosage for preventing / treatingthe synuclein disease, wherein the polypeptide analogue comprises an amino acid fragment in a transcription trans-activation protein Tat, an amino acid fragment in engineering conjugated protein beta-wrapins, and a key sequence KFERQ necessary for molecular chaperone mediated autophagy. Through the manner, the medicine and the polypeptide analogue disclosed by the application can achieve effective reference function in the respect of preventing / treating synuclein disease, and further, the polypeptide analogue can possibly achieve the effective medicine functions.

Description

technical field [0001] The present application relates to the field of medical technology, in particular to a drug and polypeptide analog for preventing / treating synuclein disease. Background technique [0002] α-synuclein is a soluble protein expressed presynaptically and perinuclearly in the central nervous system. It is closely related to the pathogenesis and related dysfunction of Parkinson's disease, and is the main component of Lewy bodies. α-synuclein is abnormally expressed and aggregated under the influence of various physiological and environmental factors, and through a series of biochemical reactions such as oxidative stress, it produces a toxic effect on neurons, thus participating in the occurrence of Parkinson's disease, etc. . α-synuclein is involved not only in familial, hereditary Parkinson's disease, but also in sporadic Parkinson's disease. High levels of alpha-synuclein are thought to be the culprit in triggering the death of dopaminergic neurons in Pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61K47/64A61P25/16C07K19/00
CPCA61K38/08A61K47/64A61P25/16C07K7/06C07K2319/10C07K2319/33
Inventor 骆倩倩王国华朱俐沈丽华胡佳楠周佳敏
Owner NANTONG UNIVERSITY
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