QuEChERS one-step type pretreatment device

A technology of inner cannula and outer cannula, which is applied in the field of QuEChERS one-step pretreatment device, can solve the problems of unavoidable transfer and pipetting process, poor separation effect of matrix and extract, and influence of system error, so as to achieve automatic drug analysis, Improve the extraction method and reduce the effect of system error

Pending Publication Date: 2019-07-19
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all the above-mentioned reagents are used to improve and optimize the reagents in the QuECh ERS method. In the process of processing, numerous transfer and pipetting processes are still unavoidable, and more consumables are required, and there will be obvious system errors that will affect the experimental results.
For the QuEChERS processing device, there is an invention that uses a centrifuge tube for extraction, purification, and separation. The patent CN 103698195 B "QuEChERS method package for efficient ho...

Method used

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  • QuEChERS one-step type pretreatment device

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Effect test

Embodiment 1

[0046] Such as figure 2 As shown, the QuEChERS method bag of the present invention's high-efficiency homogeneous extraction of drugs such as amphetamines includes: an outer sleeve, which contains an extraction reagent solution (acetonitrile mixed reagent), extraction reagent package 6 (grinding beads, anhydrous magnesium sulfate, sodium borate, etc. salting-out package); the inner casing is filled with PSA, C18 and other fillers, and the detailed structure of the inner casing is shown in figure 2 , with a porous outer wall at one end, a filter in the middle, and an organic filter membrane at the other end.

Embodiment 2

[0048] Such as figure 2 As shown, the QuEChERS method bag of the present invention's high-efficiency homogeneous extraction of drugs such as amphetamines includes: an outer sleeve, which contains an extraction reagent solution (acetonitrile mixed reagent), an extraction reagent package (salts such as grinding beads, anhydrous magnesium sulfate, and sodium borate) analysis package); the inner casing is placed with PSA, C18 and other fillers, and the detailed structure of the inner casing is shown in figure 2 , with a porous outer wall at one end, a filter in the middle, and an organic filter membrane at the other end. The extraction reagent solution and the extraction reagent package 6 are packed in a light-proof and moisture-proof tin foil bag.

[0049] The specification of the outer tube is 5ml, the extraction reagent solution (1mL acetonitrile mixed reagent), the extraction reagent package 6 includes 4~6 grinding beads, 150mg anhydrous magnesium sulfate, 30mg sodium borat...

Embodiment 3

[0051] Such as figure 1 As shown, the QuEChERS method bag of the present invention's high-efficiency homogeneous extraction of drugs such as amphetamines includes: an outer sleeve, which contains an extraction reagent solution (acetonitrile mixed reagent), an extraction reagent package (salts such as grinding beads, anhydrous magnesium sulfate, and sodium borate) analysis package); the inner casing is placed with PSA, C18 and other fillers, and the detailed structure of the inner casing is shown in figure 2 , with a porous outer wall at one end, a filter membrane in the middle, and an organic filter membrane at the other end. Outer tube 1 has a specification of 15ml, extraction reagent solution (1mL acetonitrile mixed reagent), extraction reagent package 6 includes 4 to 6 grinding beads, 150mg anhydrous magnesium sulfate, 30mg sodium borate and other salting-out packages; 20mg PSA, 10mg C18 and other fillers, the inside of the casing is 10mL, the outer wall of the inner casi...

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Abstract

The invention discloses a QuEChERS one-step type pretreatment device. The QuEChERS one-step type pretreatment device comprises an outer sleeve 1 and an inner sleeve 2 inserted into the outer sleeve; an outer tube thread 1-1 is arranged on the inner wall of an opening end of the outer sleeve 1; an inner tube thread 2-1 matched with the outer tube thread 1-1 is arranged on the outer wall of the inner sleeve, a movable piston 3 is arranged at the lower end, and a filter net 4 is arranged in the middle; an inner tube small hole 2 is formed in the tube wall between the piston 3 and the filter net 4; and the piston 3 is in sealing fit with the inner wall of the inner sleeve 2. According to the device, effective extraction of the medicine in the blood of a biological sample and purification of ablood matrix can be successfully realized, the analysis sample can be obtained in one step, and instrument analysis can be directly carried out. According to the device, the operations of the QuEChERSmethod can be completed only in the sleeve, the material is saved, and the space is saved; the device is a high-efficiency and environment-friendly pretreatment analysis device which can be widely applied to sample pretreatment of forensic medicine and forensic clinical analysis.

Description

technical field [0001] The invention relates to the field of pretreatment devices for amphetamine drug analysis, in particular to a QuEChERS one-step pretreatment device. Background technique [0002] As the most routine clinical biological sample, blood can accurately and timely reflect the concentration of drugs in the body and the status of each drug in the target organ. , non-protein nitrogenous compounds (nitrogenous substances in the blood other than protein, mainly urea, uric acid, creatine, creatinine, amino acids, ammonia, peptides, bilirubin), sugar and other organic substances, vitamins, lipids (including Steroid hormones) and other organic substances often interfere with the analysis of target substances in instrumental analysis. At present, QuEChERS is a very efficient processing method for the processing of complex matrices. [0003] The essence of QuEChERS is the derivation and further development of solid phase extraction technology and matrix solid phase di...

Claims

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Application Information

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IPC IPC(8): G01N30/06
CPCG01N30/06G01N2030/062
Inventor 刘洋何小维王羽黄强张斌扶雄
Owner SOUTH CHINA UNIV OF TECH
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