Artificial modified natural killer cell and preparation and application thereof

Abstract

The invention discloses an artificially modified natural killer (NK) cell obtained by a sugar chemical modification method and a preparation process and application thereof. According to the invention, by means of a glucose metabolism pathway, an artificially synthesized tumor targeting function is achieved, and a PD-L1 receptor on the surface of a tumor cell can be effectively blocked and is covalently coupled to the surface of an NK cell in a click chemical mode to form a target tumor killing function, and the artificially modified NK cell of an immune checkpoint PD-L1 is effectively blocked. The artificially modified natural killer cell is used for adoptive immunotherapy of tumors, effectively improves the immunotherapy effect of the tumors, and has a good clinical transformation value.

Description

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AI Technical Summary

Benefits of technology

This patented technology describes modifying certain DNA sequences called TELNACA (Teleone Connection Technologies Association Chemical Group), specifically linking them to other parts or modifications made from natural sources like bacteria or plants. These modification enhance their activity against tumors such as hepatocellular carcinoma and pancreatitis caused by viruses. They can be applied alone or combined together through genetic engineering techniques to create new types of nanoparticles containing specific recognition sites designed to bind targets associated with diseases like Hepatic Cancer. Additionally, these particles may also include an antibody attached thereto to further increase its therapeutic potential due to enhanced cell death mechanisms involved during inflammations. Overall, this innovative approach provides technical benefits over existing methods including making use of synthetic nucleotides and introducing various functionalities into NPs.

Problems solved by technology

This patented technical problem addressed in this patents relates to finding ways to treat liversomal cancer without causing harmful complications such as radiation damage caused by traditional methods like radioactive ray irradiation and chemo/therapiectomy. Current approaches involve invasively accessing organs containing these diseases, but they also pose risks that limit their effectiveness. Targeted genetically modified T lymphocytes called chimeras may provide better targets than current techniques because they act only against specific genes involved in certain disease states rather than others.

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