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A companion diagnostic method for use in the treatment of irritable bowel syndrome with dietary interventions or faecal microbiota transplant

A technology of diet and taxa, applied in biochemical equipment and methods, microbe determination/testing, disease diagnosis, etc.

Pending Publication Date: 2019-08-09
GENETIC ANALYSIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no one has raised the possibility that bacterial abundance from certain taxa may indicate that IBS subjects respond to IBS intervention diet or fecal microbiota transplantation (FMT) treatment

Method used

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  • A companion diagnostic method for use in the treatment of irritable bowel syndrome with dietary interventions or faecal microbiota transplant
  • A companion diagnostic method for use in the treatment of irritable bowel syndrome with dietary interventions or faecal microbiota transplant
  • A companion diagnostic method for use in the treatment of irritable bowel syndrome with dietary interventions or faecal microbiota transplant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0158] Example 1 - Identification of bacterial taxa capable of distinguishing IBS patients responding to a low FODMAP diet, high FOS diet or FMT from non-responders

[0159] method

[0160] Clinical studies were performed to identify taxa within the gastrointestinal microbiota that could act as a response to low FODMAP diets (as defined in Gearry RB et al., JCC 2008.09.004 8-14), high FOS diets (as defined in SlavinJ.Nutrients. 2013 Apr;5(4):1417-1435), FMT (as defined in Francis C.Y., AlimentPharmacol Ther. 1997 Apr; 11(2):395-402) a marker of responsive IBS patients.

[0161] Patients were recruited according to ROME III criteria for IBS diagnosis. Patients were classified according to their predominant symptoms into the following subtypes of IBS: diarrhea, constipation, or mixed. Microbiota profiles of stool samples from each patient before treatment and after 3–6 weeks in the dietary intervention study and after 1 and 3 weeks in the FMT study using GAmap TM Prepared ...

Embodiment 2

[0241] Example 2 - Exploring Gut Microbiota Composition as an Indicator of Clinical Response to Dietary FODMAP Restriction in Patients with Irritable Bowel Syndrome

[0242] Materials and methods

[0243] patient

[0244] IBS patients were consecutively recruited from a secondary care outpatient clinic (Lovisenberg Diaconal Hospital, Oslo, Norway) between April 2013 and October 2014. Briefly, all patients met the Rome III criteria for IBS and underwent a thorough examination by the same experienced gastroenterologist to rule out organic disease. Notably, all patients underwent 13 C-D-xylose breath test to rule out intestinal malabsorption and only 13 High levels of C-D-xylose following ingestion 13 CO 2 excreted patients.

[0245] Dietary FODMAP Restriction

[0246] All patients received nutritional counseling by experienced clinical nutritionists and were educated under the concept of low FODMAP. The baseline diet was carefully evaluated to ensure that no patients h...

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Abstract

The present invention provides a diagnostic method which may be used to determine the likelihood that a subject with Irritable Bowel Syndrome (IBS) will respond to treatment with an IBS intervention diet or faecal microbiota transplant (FMT). In particular, the method may be used to predict, or determine the likelihood of, a positive response of the subject with IBS to treatment with an IBS intervention diet or FMT, especially to determine the likelihood that the dietary intervention or FMT may have a positive (i.e. beneficial) effect on the subject's Gl tract, specifically the Gl tract microbiota, or other symptoms or complications of IBS (e.g. reducing severity thereof). The method of the present invention is based on analysing the abundance of certain bacteria in Gl tract samples, e.g.by nucleic acid analysis.

Description

technical field [0001] The present invention provides a diagnostic method that can be used to determine the likelihood that a subject with irritable bowel syndrome (IBS) will respond to treatment with IBS intervention diet or fecal microbiota transplantation (FMT). In particular, the method can be used to predict or determine the possibility that IBS patients will have a positive response to IBS intervention diet or FMT treatment, especially for determining the possible effects of diet intervention or FMT on the gastrointestinal tract of the subject, especially the gastrointestinal tract. The likelihood that the microbiota, or other symptoms or complications of IBS, will have a positive (ie beneficial) effect (eg, reduce its severity). In this way, it can be determined whether IBS or complications or symptoms of IBS in an IBS subject will improve, or whether IBS will develop in said subject, or whether after IBS intervention diet or FMT treatment Preventing or delaying said c...

Claims

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Application Information

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IPC IPC(8): C12Q1/04C12Q1/10C12Q1/689G01N33/569
CPCC12Q1/04C12Q1/10C12Q1/689G01N33/56911G01N33/56916G01N2800/065G01N2800/52C12N1/20
Inventor F·T·海格C·卡森J·瓦勒A·若瑟M·C·斯姆斯图恩
Owner GENETIC ANALYSIS
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