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Medicine containing 3-acetyl-alpha,beta-boswellic acid and application thereof in pancreatitis prevention and treatment

A technology of boswellic acid and pancreatitis, applied in the field of medicine, can solve the problems of poor therapeutic effect and lack of pancreatitis drugs, achieve the effects of small side effects, improve therapeutic effect, and inhibit pancreatic inflammation

Inactive Publication Date: 2019-08-27
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The second object of the present invention is to provide a medicine for preventing and / or treating pancreatitis, so as to alleviate the technical problems of lack of medicine for treating pancreatitis and poor therapeutic effect in the prior art

Method used

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  • Medicine containing 3-acetyl-alpha,beta-boswellic acid and application thereof in pancreatitis prevention and treatment
  • Medicine containing 3-acetyl-alpha,beta-boswellic acid and application thereof in pancreatitis prevention and treatment
  • Medicine containing 3-acetyl-alpha,beta-boswellic acid and application thereof in pancreatitis prevention and treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Stained sections of normal pancreatic tissue should have a clear structure under a light microscope, complete acinar lobules, no exudation of the medium, and no pathological changes. When pancreatitis occurs, the acinar cells in the pancreatic tissue will form vacuoles, edema, intercellular space becomes larger, inflammatory cells begin to infiltrate, and acinar cell necrosis is occasionally seen. The extent of pancreatitis development and treatment can be judged by this impaired feature. In this experimental example, control group C, model group M, 3 acetyl-α, β boswellic acid low dose treatment group D, 3 acetyl-α, β boswellic acid medium dose treatment group Z, 3 acetyl-α, β boswellic acid high dose Treatment group H conducted animal experiments in vivo, with 10 animals in each group, and studied the therapeutic effect of 3-acetyl-α, β-boswellic acid on pancreatitis through light microscope display comparison of stained sections and pancreatic histopathological scori...

Embodiment 2

[0085] In this experimental example, control group C, model group M, 3 acetyl-α, β boswellic acid low dose treatment group D, 3 acetyl-α, β boswellic acid medium dose treatment group Z, 3 acetyl-α, β boswellic acid high dose In the treatment group H, animal experiments were carried out to detect the amylase activity in the serum after the experiment, so as to study the therapeutic effect of 3-acetyl-α, β-boswellic acid on pancreatitis.

[0086] In this experimental example, C57BL / 6 mice with a body weight of about 20±2g were used for pancreatitis animal model preparation and 3-acetyl-α, β-boswellic acid treatment experiments. The experimental mice were kept at a constant temperature (22-26°C) and humidity (55-60%) in a sterile animal laboratory, fed mice with normal solid feed and water, and allowed them to acclimatize for 1 week. All in vivo experiments were carried out in accordance with the specified animal care and use guidelines, and the adoption was excellent. Cerulein i...

Embodiment 3

[0097] Example 3 Pancreatitis induces immune cell activation, exacerbates pancreatic damage, and induces systemic organ damage through various humoral factors including inflammatory cytokines. The most representative factors involved in the activation of immune cells in the pancreas to cause inflammatory responses are TNF-α, interleukin-1β (IL-1β) and interleukin-6 (IL-6). In the case of pancreatitis, serum IL-6 and TNF-α were upregulated. In this experimental example, control group C, model group M, 3 acetyl-α, β boswellic acid low dose treatment group D, 3 acetyl-α, β boswellic acid medium dose treatment group Z, 3 acetyl-α, β boswellic acid high dose Treatment group H conducted animal experiments to detect the contents of TNF-α and interleukin-6 (IL-6) in pancreatic tissue, so as to study the therapeutic effect of 3-acetyl-α and β-boswellic acid on pancreatitis.

[0098] In this experimental example, C57BL / 6 mice with a body weight of about 20±2g were used for pancreatitis...

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Abstract

The invention provides an application of 3-acetyl-alpha,beta-boswellic acid and a medicine to treat pancreatitis, and relates to the technical field of medicines. The invention confirms through experiments that 3-acetyl-alpha,beta-boswellic acid inhibits inflammation, and treats pancreatitis. Through application of 3-acetyl-alpha,beta-boswellic acid in preparation of a medicine to prevent and / or treat pancreatitis, the invention may effectively inhibit pancreas inflammation, thereby greatly improving the treatment effect of pancreatitis, so as to provide basis for clinical experiments, and provide a new approach for the development of new medicines. The active ingredient of the medicine to prevent and / or treat pancreatitis provided in the invention is 3-acetyl-alpha,beta-boswellic acid, and therefore may effectively inhibit the pancreas inflammation, so as to play a significant role in the prevention and / or treatment of pancreatitis, and the medicine is safe and non-toxic, and has small side effects.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an application of 3-acetyl-α, β-boswellic acid and a medicine for treating pancreatitis. Background technique [0002] The important role of the pancreas organ is on the one hand, exocrine function, which secretes digestive enzymes required for food digestion and absorption, and on the other hand, endocrine function, which regulates the secretion of hormones that regulate metabolism in the body, such as insulin and glucagon. Pancreatic juice contains digestive enzymes, such as amylase (to hydrolyze carbohydrates), trypsin (to hydrolyze proteins) and lipase (to hydrolyze fats). Due to alcoholism, gallstones, etc., the flow of pancreatic juice is not smooth, and the pancreas may be induced by the above enzymes. The solution develops into pancreatitis. There are two types of pancreatitis: mild pancreatitis with interstitial edema and peripancreatic fat necrosis around the pancreas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P1/18A61P29/00
CPCA61K31/56A61P1/18A61P29/00
Inventor 张盼阳杨莉白茹玉于英莉周昆曾涛宋蕾张玥孙力康
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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