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Snake gall and fritillary capsule and preparation method thereof

The technology of Shedan Chuanbei and capsule is applied in the field of Shedan Chuanbei capsule and its preparation, which can solve the problems of affecting bioavailability, need to improve the embedding rate, inconvenient transportation, etc. Beneficial effect of efficacy guarantee

Active Publication Date: 2019-09-06
HUBEI WEISHI BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Shedan Chuanbei Powder is directly crushed into medicine without extraction, so it has the disadvantages of large dosage, slow onset of action, easy growth of microorganisms, and bitter taste that most patients cannot accept.
[0004] Because Shedan Chuanbei Liquid is a syrup, it has disadvantages such as complex process, large dosage, and inconvenient transportation; and because of its high sugar content, it is easy to breed microorganisms, and it is suitable for patients who need to prohibit or control sugar intake (such as diabetics) also should not be used
[0005] Shedan Chuanbei Capsules have the characteristics of convenient transportation; however, the existing Shedan Chuanbei Capsules are usually mixed with Chuanbei mother powder and snake bile and then filled into hollow capsules, which have the following disadvantages: because the active ingredients of the original powder need to be dissolved , absorption, slow onset, affects its bioavailability to a certain extent; and the embedding rate still needs to be improved

Method used

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  • Snake gall and fritillary capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of Shedan Chuanbei Capsules comprises the steps of:

[0032] Step 1, prepare Fritillaria sichuan fine powder, Fritillaria sichuan concentrate and snake bile;

[0033] The preparation method of the fritillary fritillary concentrate is as follows: extract fritillary fritillaria with 70% ethanol for 2-4 times, then extract it with water for 2-4 times, combine the liquid extracts to obtain the concentrated liquid by vacuum, add 0.3% sorbic acid , to obtain Chuan Fritillaria concentrate.

[0034] The preparation method of the Fritillaria fine powder is as follows: take the Fritillaria coarse powder obtained after the Fritillaria powder is percolated and extracted with 70% ethanol, dry by microwave, pulverize and sieve the Fritillaria fine powder.

[0035] The preparation method of the snake bile is as follows: separate the snake gall and remove the bile coat to collect the bile → autoclaving / 115°C for 30 minutes → bile + soaking wine → snake bile

[00...

Embodiment 2

[0043] A preparation method of Shedan Chuanbei Capsules comprises the steps of:

[0044] Step 1, prepare Fritillaria sichuan fine powder, Fritillaria sichuan concentrate and snake bile, the specific preparation method is the same as in Example 1;

[0045] Step 2, mixing and concentrating the Fritillaria sichuanensis concentrated solution with snake bile to make liquid microcapsules:

[0046] S1. First, the sodium alginate solution with a concentration of 1% is mixed and stirred with snake bile, and histidine is added dropwise while stirring to obtain negatively charged sodium alginate / snake bile composite microspheres; the sodium alginate solution is mixed with snake bile The volume ratio of snake bile is 10:1; the total amount of histidine added is 1 of snake bile;

[0047] S2. Mix and stir the chitosan solution with a concentration of 5% and the fritillaria concentrate, and add polyethylene glycol 400 dropwise while stirring to obtain positively charged chitosan / fritillary ...

Embodiment 3

[0052] A preparation method of Shedan Chuanbei Capsules comprises the steps of:

[0053] Step 1, prepare Fritillaria sichuan fine powder, Fritillaria sichuan concentrate and snake bile, the specific preparation method is the same as in Example 1;

[0054] Step 2, mixing and concentrating the Fritillaria sichuanensis concentrated solution with snake bile to make liquid microcapsules:

[0055] S1. First, the sodium alginate solution with a concentration of 5% is mixed and stirred with snake bile, and histidine is added dropwise while stirring to obtain negatively charged sodium alginate / snake bile composite microspheres; the sodium alginate solution is mixed with snake bile The volume ratio of snake bile is 20:1; the total amount of histidine added is 5% of snake bile;

[0056] S2. Mix and stir the chitosan solution with a concentration of 1% and the fritillaria concentrated solution, and add polyethylene glycol 400 dropwise while stirring to obtain positively charged chitosan / ...

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Abstract

The invention discloses a snake gall and fritillary capsule and a preparation method thereof. The method includes the following steps: (1) preparing a fritillary bulb concentrated solution, snake bileand fritillary bulb fine powder; (2) mixing and concentrating the fritillary bulb concentrated solution and the snake bile to prepare a liquid microcapsule; (3) granulating and drying the fritillarybulb fine powder to obtain fritillary granules; and (4) uniformly mixing the microcapsule obtained in the step 2 and the fritillary bulb particles obtained in the step 3, and filling the mixture intoa hollow capsule to obtain the snake gall and fritillary capsule. The snake gall and fritillary capsule prepared by the method has the advantages of snake gall and fritillary liquid and the snake galland fritillary bulb capsule: the fritillary bulb concentrated solution and the snake bile are mixed to prepare the liquid microcapsule, so that the liquid absorption effect in the microcapsules is good, and the bioavailability is improved; the fritillary bulb particles obtained by granulating and drying the fritillary bulb fine powder are mixed with liquid microcapsule and filled into the hollowcapsule, so that the embedding rate is improved, and the stability is good; and the capsule is easy to store and transport.

Description

technical field [0001] The invention relates to the field of food biotechnology, in particular to a Shedan Chuanbei capsule and a preparation method thereof. Background technique [0002] Shedan Chuanbei Capsules, with Chuanbeimu and snake bile as the main ingredients, has the effects of clearing the lungs, relieving cough, and eliminating phlegm. It is usually used for cough due to lung heat and excessive phlegm. In addition, there are Shedan Chuanbei Powder and Shedan Chuanbei Liquid. The 2015 edition of the Chinese Pharmacopoeia contains Shedan Chuanbei Capsules and Shedan Chuanbei Powder. . [0003] Shedan Chuanbei Powder is directly crushed into medicine without extraction, so it has the disadvantages of large dosage, slow onset of action, easy growth of microorganisms, and bitter taste, which is not acceptable to most patients. [0004] Because Shedan Chuanbei Liquid is a syrup, it has disadvantages such as complex process, large dosage, and inconvenient transportati...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61K9/50A61K47/36A61K47/10A61K47/18A61P11/00A61P11/10A61P11/14A61K35/583
CPCA61K36/8966A61K35/583A61K9/5036A61K47/183A61K47/10A61P11/00A61P11/14A61P11/10A61K9/1652A61K2236/30A61K2300/00
Inventor 罗先隽
Owner HUBEI WEISHI BIO PHARMA
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