A dye for early diagnosis of esophageal cancer and its preparation method

Abstract

The invention discloses a staining agent for early diagnosis of esophageal cancer and a preparation method thereof, and the application of xanthan gum in the iodine staining agent for living body staining. In terms of weight percentage, the dyeing agent comprises: 0.05-0.1 percent of xanthan gum, 0.5-1 percent of iodine, potassium iodide 1.25-1.5 times the weight of iodine, and the balance is water. A certain ratio of xanthan gum, iodine and potassium iodide is used to compound, while reducing the content of iodine and potassium iodide, it can provide a long enough dyeing time, has little impact on patients, is safe to use, can effectively save examination time, and reduce anesthesia drugs The dosage is increased, the indications for inspection are expanded, and the preparation cost is low, which has good economic and social benefits.

Description

technical field [0001] The invention relates to the technical field of medical detection reagents, in particular to a dye for early diagnosis of esophageal cancer, its preparation method and the application of xanthan gum in iodine dye for living body dyeing. Background technique [0002] Esophageal cancer is a common digestive tract tumor; my country is an area with a high incidence of esophageal cancer, and more than 150,000 people die each year. Most patients with esophageal cancer have developed to the middle or late stage when they come to the hospital for treatment. The clinical curative effect of the middle and late stage patients is poor and the cost is high. Therefore, it is of great significance to carry out early diagnosis of esophageal cancer. A common method for early diagnosis of esophageal cancer is: spray the pre-prepared iodine-containing solution to the patient's esophageal mucosa through a gastroscope, and observe the color change of the mucosa. The squa...

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Problems solved by technology

[0004] (1) Lugol's iodine solution is highly irritating to patients' esophageal mucosa. During use, the patient's esophageal mucosa is prone to spasm and contraction, which seriously affects the doctor's observation of lesions and sampling and biopsy. Among patients with esophageal cancer, middle-aged and elderly people The proportion is much higher than that of young people, and the proportion of middle-aged and elderly patients with heart disease is relatively high, and it is easy to induce arrhythmia under the adverse stimulation of iodine solution; although the iodine content of the diluted solution is significantly lower than that of the original solution, some patients still have heartburn, Chest pain, nausea, vomiting, allergies and other adverse reactions;

[0005] (2) In order to eliminate the irritation of iodine solution, the esophagus needs to be flushed with buffer solution after staining, which increases the medical cost and the time of gastroscopy examination, and the increase of operation time also means that the amount of anesthesia, sedation and other drugs used during the examination increase, which is bound to be accompanied by an increase in drug toxicity and side effects, and at the same time, the medical expenses borne by patients also increase accordingly;

[0006] (3) Patients with thyroid disease need to strictly control iodine intake, and patients with hyperkalemia need to strictly limit potassium intake. The iodine content and potassium content of Lugol's iodine solution are high. adverse effects on patients

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