Application of Small Molecular Fucoidan in the Preparation of Medicines for Preventing Pneumonia Caused by Radiation

Abstract

The present invention relates to the use of small molecule fucoidan in the preparation of medicines for preventing pneumonia caused by radiation, which can reduce pneumonia by reducing cytokines and lymphocyte hyperplasia, and simultaneously achieve the effect of reducing pulmonary fibrosis.

Description

technical field [0001] The present invention relates to a use, in particular to the use of small molecule fucoidan pharmaceuticals for preventing pneumonia caused by radiation. Background technique [0002] Malignant tumors have been a threat to humans for more than a century, and tens of thousands of scientists around the world are working on solving malignant tumors. The reason why malignant tumors pose such a huge threat to human beings is that, in addition to the uncertainty of the tumor itself and its ever-changing characteristics, it also causes huge damage to the functions of human organs. At the same time, it is usually difficult to completely eradicate once discovered. Among them, most of the malignant tumors, especially those located in the thoracic cavity or abdominal cavity, are difficult to remove by surgery; if chemotherapy is given, it will also affect other body organs; and most of the common target drugs in recent years are still In the development stage, i...

AI Technical Summary

Problems solved by technology

[0003] Radiation therapy is a treatment method that uses high-energy radiation to kill or shrink malignant tumors. Depending on the type of tumor, location of growth, tumor status, and patient health, the intensity of radiation therapy used is also different. Side effects such as mild skin problems, nausea, vomiting, and tiredness usually disappear after a short period of time; however, after radiation therapy for tumors near the chest, the patient's lungs may cause lung disease due to radiation, such as Inflammation (Radiation pneumonia), usually the aforementioned inflammation occurs 4 to 12 weeks after radiotherapy, and may also occur 1 week after radiotherapy in patients receiving higher doses of radiotherapy

The inflammation of the lungs may turn into serious side effects such as pulmonary fibrosis 6 weeks to several years after radiotherapy. Pulmonary fibrosis will thicken the tissue wall of the lung tissue, resulting in an irreversible oxygen exchange capacity of the lung tissue, resulting in a gradual loss of lung function. , poor prognosis

[0004] According to the existing technology, the disease process from chemotherapy to pulmonary fibrosis is difficult to prevent or treat, and no research has proposed a treatment or preventive method that can effectively prevent lung damage. Therefore, patients receiving thoracic radiation therapy suffer from Risk of pulmonary fibrotic disease, therefore radiation-induced pulmonary fibrosis remains an important problem in medicine today

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