Application of erucamide in preparation of medicine for treating myocardial injury

A technology for erucamide and myocardial injury, which can be applied in drug combinations, amide active ingredients, and pharmaceutical formulations, and can solve problems such as unclear mechanisms of action
CN110237060BActive Publication Date: 2021-12-07GUANGDONG PHARMA UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGDONG PHARMA UNIV
Publication Date
2021-12-07

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Abstract

The invention proposes a new application of erucamide, in particular the application of erucamide in the preparation of medicine for treating myocardial injury. Through the stress ulcer animal model established by the present invention, it was found that erucamide has a protective effect on the heart of water immersion-restraint stress mice, and by Western Blot analysis, it was found that BCL-2 and BAX appeared after using erucamide. The biological effect was consistent with that of the positive control drug metoprolol, and the results suggested that erucamide had a certain anti-stress myocardial injury effect in mice, and was related to BCLโ€‘2 and BAX signaling pathways.
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Description

technical field

[0001] The present invention relates to a new application of erucamide, in particular, the present invention relates to the application of erucamide in the preparation of medicine for treating myocardial injury. Background technique

[0002] Erucamide is a long-chain unsaturated amide and a biologically active fatty acid amide, similar to the classic endocannabinoid analogue oleoylethanolamide (OEA). Erucic acid amide is synthesized under normal pressure with erucic acid and ammonia as raw materials under the catalysis of rare earth metal compounds. This product is a powdery or small bead-like white color solid, non-toxic and odorless. Insoluble in water, soluble in alcohol, ether, ester, ketone, benzene and other organic solvents.

[0003] Erucamide is a fatty acid amide, like oleamide and anandamide, that regulates other physiological functions in a receptor-mediated manner. All of the exact biological functions of erucamide have not yet been defined, bu...

Claims

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