Treatment of autoimmune diseases

A technology for autoimmune diseases and self-antigens, applied in allergic diseases, skin diseases, gene therapy, etc., can solve the problems of little known etiology, no treatment, no therapy, etc.

Pending Publication Date: 2019-09-17
LOMA LINDA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, in the case of androgenetic alopecia, there is no adequate treatment, and in the case of alopecia areata, little is even known about its cause
[0022] As described above, among all types of alopecia, the types of alopecia that are difficult to treat are alopecia areata and androgenetic alopecia, and for alopecia areata in particular, there are few effective treatments
Additionally, there are few treatments for postpartum alopecia, female pattern alopecia, pityriasis alopecia, senile alopecia, and cancer chemotherapy drug-induced alopecia

Method used

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  • Treatment of autoimmune diseases

Examples

Experimental program
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Embodiment 1

[0123] Embodiment 1.DNA vaccine is used for the purposes of treating alopecia areata

[0124] Preparation of plasmid DNA constructs encoding pro-apoptotic proteins. The pro-apoptotic protein is selected from: Bax, Bak, Bim, Puma, Bad, Bik, Noxa, Bmf, Hrk, Bid, FAS, caspase mutants or survivin mutants. Plasmids were isolated from bacterial strains that hypermethylated CpG dinucleotides and bacterial strains that did not hypermethylate (ie, hypomethylate) CpG dinucleotides. In the case of hypermethylated DNA constructs, promoters controlling the transcription of genes / cDNAs encoding pro-apoptotic proteins are not inactivated by CpG hypermethylation, such as the SV40 promoter. In the case of non-hypermethylated constructs, the promoter may be any inducible or constitutive promoter, such as the CMV or LTR promoter.

[0125] Each plasmid DNA construct or different combinations of the two constructs in different ratios are then delivered to the skin to treat alopecia areata, eg, u...

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Abstract

The invention relates to treatment of autoimmune diseases, and particularly discloses compositions for treatment of autoimmune diseases or conditions that result in hair loss, such as alopecia. The compositions include first and second polynucleotides, wherein a) the first polynucleotide comprises a sequence encoding an autoantigen or an antigenic fragment thereof, with at least about 50% of CpG dinucleotide of the first polynucleotide being methylated; and b) the second polynucleotide comprises a sequence encoding a pro-apoptotic protein, or a functional pro-apoptotic fragment thereof, with the pro-apoptotic protein being selected from a group consisting of BAK, BAX, BIM, a death receptor 4, a death receptor 5 or a FAS receptor, wherein 15% or less of said CpG dinucleotide of the second polynucleotide is methylated. The compositions are used intradermally for inducing a tolerogenic immune response against said autoantigen.

Description

[0001] The present invention is a divisional application of a Chinese patent application with the application number 201480015896.9, the application date is March 14, 2014, and the invention title is "Treatment of Autoimmune Diseases". [0002] related application [0003] This application claims the benefit of US Patent Application No. 61 / 800,354, filed March 15, 2013; the entire teachings of this application are incorporated herein by reference. [0004] sequence listing [0005] This application contains the Sequence Listing, filed electronically as an ASCII file, and is hereby incorporated by reference in its entirety. The ASCII copy is named 088025-0076_SL.txt, was created on September 22, 2015, and is 1,119 bytes in size. technical field [0006] The subject technology generally relates to compositions and methods for treating autoimmune diseases or disorders, particularly autoimmune diseases or disorders that result in hair loss such as alopecia. Background techniqu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K39/00A61K38/17A61P37/02
CPCC12N2830/46C12N15/85C12N2800/107A61P17/14A61P37/02A61P37/06Y02A50/30
Inventor A·P·埃舍尔
Owner LOMA LINDA UNIVERSITY
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