Treatment of autoimmune diseases

Abstract

The invention relates to treatment of autoimmune diseases, and particularly discloses compositions for treatment of autoimmune diseases or conditions that result in hair loss, such as alopecia. The compositions include first and second polynucleotides, wherein a) the first polynucleotide comprises a sequence encoding an autoantigen or an antigenic fragment thereof, with at least about 50% of CpG dinucleotide of the first polynucleotide being methylated; and b) the second polynucleotide comprises a sequence encoding a pro-apoptotic protein, or a functional pro-apoptotic fragment thereof, with the pro-apoptotic protein being selected from a group consisting of BAK, BAX, BIM, a death receptor 4, a death receptor 5 or a FAS receptor, wherein 15% or less of said CpG dinucleotide of the second polynucleotide is methylated. The compositions are used intradermally for inducing a tolerogenic immune response against said autoantigen.

Description

[0001] The present invention is a divisional application of a Chinese patent application with the application number 201480015896.9, the application date is March 14, 2014, and the invention title is "Treatment of Autoimmune Diseases". [0002] related application [0003] This application claims the benefit of US Patent Application No. 61 / 800,354, filed March 15, 2013; the entire teachings of this application are incorporated herein by reference. [0004] sequence listing [0005] This application contains the Sequence Listing, filed electronically as an ASCII file, and is hereby incorporated by reference in its entirety. The ASCII copy is named 088025-0076_SL.txt, was created on September 22, 2015, and is 1,119 bytes in size. technical field [0006] The subject technology generally relates to compositions and methods for treating autoimmune diseases or disorders, particularly autoimmune diseases or disorders that result in hair loss such as alopecia. Background techniqu...

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Problems solved by technology

Also, in the case of androgenetic alopecia, there is no adequate treatment, and in the case of alopecia areata, little is even known about its cause

[0022] As described above, among all types of alopecia, the types of alopecia that are difficult to treat are alopecia areata and androgenetic alopecia, and for alopecia areata in particular, there are few effective treatments

Additionally, there are few treatments for postpartum alopecia, female pattern alopecia, pityriasis alopecia, senile alopecia, and cancer chemotherapy drug-induced alopecia

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