Medical instrument

A technology of medical devices and adherents, applied in the field of medical devices, can solve the problems of increasing operation complexity and risk of use, affecting patient compliance, etc., and achieves the effect of simple operation, low cost and improved release

Inactive Publication Date: 2019-10-15
万平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] To replace obesity and/or diabetes surgery, the duodenal cannula or duodenal endoplasty inserted into the duodenum through the natural orifice reduces the risk of the first-generation or second-generation surgery, but both For medical devices implanted in

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0012] The enteric-coated hard capsule is the outer phase, and the liquid or semi-solid adherend filled into the hard capsule is the inner phase, which can be made of polyethylene glycol, acryloyl chloride, NVP and acrylic acid. Available high-efficiency coating machine, nozzle diameter 0.5-l.5mm, atomization pressure 0.1MPa, air volume 50-120m3 / h, material temperature 23-25°C, spray speed 0.5-5.5g / min, 25°C aging 20-60min , take out, and dry at room temperature; enteric coating materials can be Eudragit L type, Eudragit S type, acrylic resin No. 1 and other acrylic resins, hydroxypropyl methylcellulose phthalate and other cellulose derivatives, etc. and other smart materials. Fill enteric-coated empty capsules, seal with 5-15% ethyl cellulose solution, and place in a desiccator for later use. An appropriate amount of anti-adherent magnesium stearate or silicon dioxide, etc. (to prevent liquid adherents from adhering to the capsule shell), or diluents, lubricants, disintegran...

Embodiment 2

[0014] The enteric-coated hard capsule is the outer phase, and the liquid adherent filled into the hard capsule is the inner phase. The enteric-coated capsule material can be hydroxypropyl methylcellulose phthalate or other intelligent response materials, 400g HPMCP, 1000g alginic acid, 1000g gelatin, 10g PEG, appropriate amount of deionized water to adjust the concentration, and 10% alkaline solution to adjust the pH to 8. For mixing, add an appropriate amount of anti-adherent magnesium stearate or silicon dioxide (to prevent liquid adherents from adhering to the capsule shell), or diluents, lubricants, disintegrants, etc., stir, and dip in glue to form. Excipients can choose polyethylene glycol or polyalkylene or stearic acid derivatives or semi-synthetic glyceride derivatives that are incompatible with the shell; the dynamic viscosity should not be too high or too low to avoid tailing and splashing liquid; the filling surface tension should not be too low, so as to avoid ea...

Embodiment 3

[0016] Enteric-coated hard capsules are the outer phase, and the semi-solid (semi-liquid) adherents filled into the hard capsules are the inner phase. Alkyl methacrylate monomer (AMA), diethylaminoethyl methacrylate ( DEA), made with a cross-linking agent; N-vinylpyrrolidone (NVP) and β-hydroxyethyl methacrylate (HEMA) can also be used for free radical polymerization and copolymerization, and acrylamide with multiple responses to temperature and pH ( AAm) introduced, can also be prepared with N-phosphorylated chitosan derivatives (NPCP). The enteric-coated capsule material is a mixture of Eudragit NE-30D and Eudrasit L30D-55 or other pH intelligent response materials. Formaldehyde impregnation method, coating method, film coating method or raw material mixing method can be used for preparation; conventionally filled into enteric-coated empty capsules. According to the methods of "Pharmaceuticals" and "Pharmacopia" and other existing technologies and standards to investigate t...

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Abstract

The invention discloses a positioning adhesive object. The positioning adhesive object is used for the preparation of a medical instrument for preventing or treating diabetes or obesity or duodenal inflammation or ulcer to replace the application of products such as bariatric surgery, diabetes surgery, duodenal cannula (inner lamella), an isolating membrane tube and a deflector in the medical instrument; and at least a part of the biocompatible adhesive object is in a liquid or semi-solid state, at least a part of the biocompatible adhesive object is made of a smart material, and at least a part of the biocompatible adhesive object is positioned and adheres to duodenum.

Description

[0001] This application can be a Chinese invention patent dated May 5, 2012 (application number 201210136379.X), August 21, 2012 (application number 201210298363.9), January 28, 2013 (application number 201310029525.3), March 31, 2013 (Application No. 201310107770.1), July 18, 2013 (Application No. 201310301366.8), January 4, 2016 (Application No. 201610001029.0) and June 20, 2019 (Application No. 201910538674.X), and PCT published on July 31, 2014 (WO2014 / 114255, PCT / CN2014 / 071294) and the partial continuation of the corresponding national patents. technical field [0002] The present invention relates to a medical device (mainly preventing and treating diseases through physical and non-pharmacological methods), in particular to a replacement for bariatric surgery, diabetes surgery, duodenal cannula (inner coating), isolation membrane tube, flow guide, etc. Application of the product in medical devices and its preparation method. Background technique [0003] First-generat...

Claims

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Application Information

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IPC IPC(8): A61F5/00
CPCA61F5/0076
Inventor 万平
Owner 万平
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