Preparation method of three-dimensional porous antibacterial silk fibroin/graphene/titanium dioxide bone tissue engineering scaffold
A technology of bone tissue engineering and titanium dioxide, used in tissue regeneration, pharmaceutical formulations, prostheses, etc., can solve the problems of poor antibacterial properties, unsatisfactory mechanical properties of scaffolds, and poor osteoinductive ability, and achieves promotion of dispersion and improved mechanical properties. Performance, easy-to-get results
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[0028] Example 1:
[0029] 1) Use boiling mass percentage of 0.5%~1% sodium carbonate (Na 2 CO 3 ) The aqueous solution degummed the cocoons. After degumming, they were dissolved in a LiBr aqueous solution with a molar concentration of 9.0±0.5 mol / L. After centrifugation, filtration, and dialysis to remove impurities and LiBr, the RSF aqueous solution was obtained and concentrated to the RSF mass fraction 2% solution A is ready for use. The dialysis is to put the RSF solution after centrifugal suction filtration into a cellulose dialysis bag. After sealing, it is immersed in deionized water to start dialysis. The dialysis temperature is 6~12°C, the dialysis time is 72 hours, and the water change cycle is 3~ 4 h.
[0030] 2) Mix 0.5~4 mg / mL GO dispersion liquid, 10~30% TiO 2 The hydrosol is blended with ethanol with a volume percentage of 25% and a volume of 100 mL to control GO and TiO 2 The mass ratio is 1:5, and it is placed in an ultrasonic disperser after ultrasonic dispersion...
Example Embodiment
[0035] Example 2:
[0036] The difference between embodiment 2 and embodiment 1 is that embodiment 2 controls rGO@TiO 2 The mass ratio of RSF to RSF is 1:50, and Example 1 controls rGO@TiO 2 The mass ratio to RSF is 1:100, and other operations are the same as in Example 1, as follows:
[0037] 1) Use boiling mass percentage of 0.5%~1% sodium carbonate (Na 2 CO 3 ) The aqueous solution degummed the cocoons. After degumming, they were dissolved in a LiBr aqueous solution with a molar concentration of 9.0±0.5 mol / L. After centrifugation, filtration, and dialysis to remove impurities and LiBr, the RSF aqueous solution was obtained and concentrated to the RSF mass fraction 2% solution A is ready for use. The dialysis is to put the RSF solution after centrifugal suction filtration into a cellulose dialysis bag. After sealing, it is immersed in deionized water to start dialysis. The dialysis temperature is 6~12°C, the dialysis time is 72 hours, and the water change cycle is 3~ 4 h.
[003...
Example Embodiment
[0043] Example 3:
[0044] The difference between Example 3 and Example 2 is that Example 3 controls rGO@TiO 2 The mass ratio to RSF is 1:20, and the second embodiment controls rGO@TiO 2 The mass ratio to RSF is 1:50, and other operations are the same as in Example 2, as follows:
[0045] 1) Use boiling mass percentage of 0.5%~1% sodium carbonate (Na 2 CO 3 ) The aqueous solution degummed the cocoons. After degumming, they were dissolved in a LiBr aqueous solution with a molar concentration of 9.0±0.5 mol / L. After centrifugation, filtration, and dialysis to remove impurities and LiBr, the RSF aqueous solution was obtained and concentrated to the RSF mass fraction 2% solution A is ready for use. The dialysis is to put the RSF solution after centrifugal suction filtration into a cellulose dialysis bag. After sealing, it is immersed in deionized water to start dialysis. The dialysis temperature is 6~12°C, the dialysis time is 72 hours, and the water change cycle is 3~ 4 h.
[0046] 2)...
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